ArticleBiomicrofluidics2017
Generating 2-dimensional concentration gradients of biomolecules using a simple microfluidic design.
Article in Biomicrofluidics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Organ-on-a-Chip:Pharmaceutics · 2024Article
- The Fabrication and Bonding of Thermoplastic Microfluidics: A Review.Materials (Basel, Switzerland) · 2022Review
- Self-Cleaning Ceramic Tiles Produced via Stable Coating of TiO₂ Nanoparticles.Materials (Basel, Switzerland) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study reports a microfluidic device for generating 2-dimensional concentration gradients of biomolecules along the width and length of a chamber and conventional 1-dimensional gradients along the width of its lateral parallel channels. The gradient profile can be precisely controlled by the applied flow rate. The proposed design is simple and straightforward, has a small footprint size compared to previously reported devices such as tree-shape designs, and for the first time, provides capability of generating desired 2D and 1D gradients, simultaneously. The finite element simulation analysis proves the feasibility of the microfluidic device, and the fluorescently labelled IgG antibody is used to demonstrate generated chemical gradients. This simple microfluidic device can be implemented for a wide range of high-throughput concentration gradient applications such as chemotaxis, drug screening, and organs-on-chips.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.