Evidence map›Paper›PMID 28852427›Full record

ArticleClinical epigenetics2017

Seven-CpG-based prognostic signature coupled with gene expression predicts survival of oral squamous cell carcinoma.

Sipeng Shen, Guanrong Wang, Qianwen Shi, Ruyang Zhang, Yang Zhao, Yongyue Wei, Feng Chen, David C Christiani

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In one paragraph

Article in Clinical epigenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sipeng ShenDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Guanrong WangNational Health and Family Planning Commission Contraceptives Adverse Reaction Surveillance Center, Jiangsu Institute of Planned Parenthood Research, Nanjing, China.
Qianwen ShiDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Ruyang ZhangDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Yang ZhaoDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Yongyue WeiDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Feng ChenDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
David C Christiani *China International Cooperation Center of Environment and Human Health, Nanjing Medical University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDNA methylation has started a recent revolution in genomics biology by identifying key biomarkers for multiple cancers, including oral squamous cell carcinoma (OSCC), the most common head and neck squamous cell carcinoma.

methodsA multi-stage screening strategy was used to identify DNA-methylation-based signatures for OSCC prognosis. We used The Cancer Genome Atlas (TCGA) data as training set which were validated in two independent datasets from Gene Expression Omnibus (GEO). The correlation between DNA methylation and corresponding gene expression and the prognostic value of the gene expression were explored as well.

resultsThe seven DNA methylation CpG sites were identified which were significantly associated with OSCC overall survival. Prognostic signature, a weighted linear combination of the seven CpG sites, successfully distinguished the overall survival of OSCC patients and had a moderate predictive ability for survival [training set: hazard ratio (HR) = 3.23,

conclusionPrognostic signature integrated of DNA methylation, gene expression, and clinical information provides a better prognostic prediction value for OSCC patients than that with clinical information only.

Indexed as

CpG IslandsAdultAgedAged, 80 and overArea Under CurveCarcinoma, Squamous CellDatabases, GeneticDNA MethylationFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMiddle AgedMouth NeoplasmsPrognosisGene expressionMethylationOral squamous cell carcinomaOverall survivalPrognostic signature

Identifiers

PMID28852427
PMCPMC5571486

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.