ArticleWorld journal of gastroenterology2017
Crohn's disease environmental factors in the developing world: A case-control study in a statewide catchment area in Brazil.
Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Epidemiology of inflammatory bowel disease in South America: A systematic review.World journal of gastroenterology · 2019Pooled it
- Parental and perinatal risk factors associated with onset of IBD: a systematic literature review and meta-analysis.Frontiers in gastroenterology (Lausanne, Switzerland) · 2025Review
- An Overview of the Influence of Breastfeeding on the Development of Inflammatory Bowel Disease.Nutrients · 2023Review
- Evaluating the influence of environmental risk factors on inflammatory bowel diseases: a case-control study.Gastroenterology and hepatology from bed to bench · 2023Article
- Early life exposures and the risk of inflammatory bowel disease: Systematic review and meta-analyses.EClinicalMedicine · 2021Article
- Real-world disease activity and sociodemographic, clinical and treatment characteristics of moderate-to-severe inflammatory bowel disease in Brazil.World journal of gastroenterology · 2021Article
- Risk factors associated with inflammatory bowel disease: A multicenter case-control study in Brazil.World journal of gastroenterology · 2020Article
- Effect of Age on the Initiation of Biologic Agent Therapy in Patients With Inflammatory Bowel Disease: Korean Common Data Model Cohort Study.JMIR medical informatics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo identify environmental risk factors associated with the development of Crohn's disease (CD) in order to re-assess the hygiene hypothesis.
methodsA hospital-based, case-control study was carried out with CD patients (
resultsOn the univariate analysis, predictive variables for CD included being male, under age of 40, a high education level, urban dweller, smaller family size, exposure to enteric pathogens and user of treated water (
conclusionMost variables supporting the "hygiene hypothesis" are associated with the development of CD but are not independent predictors of the diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.