Evidence map›Paper›PMID 28852309›Full record

ArticleWorld journal of gastroenterology2017

Everolimus halts hepatic cystogenesis in a rodent model of polycystic-liver-disease.

Frederik Temmerman, Feng Chen, Louis Libbrecht, Ingrid Vander Elst, Petra Windmolders, Yuanbo Feng, Yicheng Ni, Humbert De Smedt, Frederik Nevens, Jos van Pelt

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Frederik TemmermanFrederik Temmerman, Ingrid Vander Elst, Petra Windmolders, Frederik Nevens, Jos van Pelt, Laboratory of Hepatology, Department of Clinical and Experimental Medicine, Faculty of Medicine, University of Leuven, B 3000 Leuven, Belgium.
Feng ChenFrederik Temmerman, Ingrid Vander Elst, Petra Windmolders, Frederik Nevens, Jos van Pelt, Laboratory of Hepatology, Department of Clinical and Experimental Medicine, Faculty of Medicine, University of Leuven, B 3000 Leuven, Belgium.
Louis LibbrechtFrederik Temmerman, Ingrid Vander Elst, Petra Windmolders, Frederik Nevens, Jos van Pelt, Laboratory of Hepatology, Department of Clinical and Experimental Medicine, Faculty of Medicine, University of Leuven, B 3000 Leuven, Belgium.
Ingrid Vander ElstFrederik Temmerman, Ingrid Vander Elst, Petra Windmolders, Frederik Nevens, Jos van Pelt, Laboratory of Hepatology, Department of Clinical and Experimental Medicine, Faculty of Medicine, University of Leuven, B 3000 Leuven, Belgium.
Petra WindmoldersFrederik Temmerman, Ingrid Vander Elst, Petra Windmolders, Frederik Nevens, Jos van Pelt, Laboratory of Hepatology, Department of Clinical and Experimental Medicine, Faculty of Medicine, University of Leuven, B 3000 Leuven, Belgium.
Yuanbo FengFrederik Temmerman, Ingrid Vander Elst, Petra Windmolders, Frederik Nevens, Jos van Pelt, Laboratory of Hepatology, Department of Clinical and Experimental Medicine, Faculty of Medicine, University of Leuven, B 3000 Leuven, Belgium.
Yicheng NiFrederik Temmerman, Ingrid Vander Elst, Petra Windmolders, Frederik Nevens, Jos van Pelt, Laboratory of Hepatology, Department of Clinical and Experimental Medicine, Faculty of Medicine, University of Leuven, B 3000 Leuven, Belgium.
Humbert De SmedtFrederik Temmerman, Ingrid Vander Elst, Petra Windmolders, Frederik Nevens, Jos van Pelt, Laboratory of Hepatology, Department of Clinical and Experimental Medicine, Faculty of Medicine, University of Leuven, B 3000 Leuven, Belgium.
Frederik NevensFrederik Temmerman, Ingrid Vander Elst, Petra Windmolders, Frederik Nevens, Jos van Pelt, Laboratory of Hepatology, Department of Clinical and Experimental Medicine, Faculty of Medicine, University of Leuven, B 3000 Leuven, Belgium.
Jos van PeltFrederik Temmerman, Ingrid Vander Elst, Petra Windmolders, Frederik Nevens, Jos van Pelt, Laboratory of Hepatology, Department of Clinical and Experimental Medicine, Faculty of Medicine, University of Leuven, B 3000 Leuven, Belgium.
Ghent University Hospital · BEZhejiang University · CNKU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo develop a MRI-based method for accurate determination of liver volume (LV) and to explore the effect of long-term everolimus (EVR) treatment on LV in PCK rats with hepatomegaly.

methodsThirty-one female PCK rats (model for polycystic-liver-disease: PCLD) were randomized into 3 groups and treatment was started at 16 wk, at the moment of extensive hepatomegaly (comparable to what is done in the human disease). Animals received: controls (

resultsLV determination by MRI correlated excellent with the

conclusionEverolimus halts cyst growth comparable to lanreotide and reduces the development of fibrosis. mTOR-inhibition should be further explored in PCLD patients especially those that need immunosuppression.

Indexed as

AnimalsCystsDisease Models, AnimalDrug Evaluation, PreclinicalEverolimusFemaleGene Expression ProfilingHumansHypertension, PortalLiverLiver CirrhosisLiver DiseasesMagnetic Resonance ImagingPeptides, CyclicPhosphatidylinositol 3-KinasesPhosphorylationEverolimuslanreotidePeptides, CyclicPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRibosomal Protein S6SomatostatinTOR Serine-Threonine KinasesFibrocystic liver diseaseLiver volume measurementMagnetic resonance imagingmTOR inhibitorSomatostatin analogue

Identifiers

PMID28852309
PMCPMC5558113
OpenAlexW2749422515

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.