ArticleScientific reports2017
Probe-based confocal laser endomicroscopy for in vivo evaluation of the tumor vasculature in gastric and rectal carcinomas.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Review
- The role of confocal laser endomicroscopy in pediatric gastrointestinal diseases: a narrative review.Frontiers in pediatrics · 2025Review
- Mini-Invasive Pleural Probe-Based Confocal Laser Endomicroscopy for Malignant Pleural Effusion Diagnosis.Respiration; international review of thoracic diseases · 2025Article
- The LMIT: Light-mediated minimally-invasive theranostics in oncology.Theranostics · 2024Review
- pCLE detects mucosal neoplastic vascular pattern in gastric linitis plastica.Clinical and experimental medicine · 2023Article
- Assessments of microvascular function in organ systems.American journal of physiology. Heart and circulatory physiology · 2022Review
- Extramural vascular invasion nomogram before radical resection of rectal cancer based on magnetic resonance imaging.Frontiers in oncology · 2022Article
- pCLE highlights distinctive vascular patterns in early gastric cancer and in gastric diseases with high risk of malignant complications.Scientific reports · 2021Article
- Reduced Intravenous Fluorescein Dose for Upper and Lower Gastrointestinal Tract Probe-Based Confocal Laser Endomicroscopy.Clinical endoscopy · 2021Article
- Diagnosis of Clinical Complete Response by Probe-Based Confocal Laser Endomicroscopy (pCLE) After Chemoradiation for Advanced Rectal Cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Article
- Deregulated expression of Elastin Microfibril Interfacer 2 (EMILIN2) in gastric cancer affects tumor growth and angiogenesis.Matrix biology plus · 2020Article
- The Probe Based Confocal Laser Endomicroscopy (pCLE) in Locally Advanced Gastric Cancer: A Powerful Technique for Real-Time Analysis of Vasculature.Frontiers in oncology · 2019Article
- Probe-based confocal laser endomicroscopy (pCLE) is a suitable method for extrapulmonary high grade neuroendocrine rectal carcinoma (HGNEC) evaluation.OncoTargets and therapy · 2019Article
- Loss of Multimerin-2 and EMILIN-2 Expression in Gastric Cancer Associate with Altered Angiogenesis.International journal of molecular sciences · 2018Article
- Probe-based confocal endomicroscopy is accurate for differentiating gastric lesions in patients in a Western center.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2018Article
- Inhibition of the CCL5/CCR5 Axis against the Progression of Gastric Cancer.International journal of molecular sciences · 2018Review
- Probing the gut barrier: epithelial permeability as a dynamic marker in eosinophilic gastroenteritis via pCLE.Therapeutic advances in gastrointestinal endoscopyArticle
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Probe-based Confocal Laser Endomicroscopy (pCLE) is a powerful imaging technique that allows to perform gastrointestinal endomicroscopy at subcellular resolution. The aim of this study was to assess the use of pCLE to evaluate tumor angiogenesis in rectal and gastric cancers. A total of 35 consecutive patients with gastric and 91 with rectal carcinomas underwent endoscopy and pCLE during the same examination. Vascular assessment was based on vessel shape and size, vessel permeability and blood flow, and allowed the creation of an angiogenic score ranging from 0, for normal vasculature, to 4, for aberrant vasculature. A significant difference for the presence of vessels with large diameter and defective blood flow was found between rectal and gastric cancers. Overall, rectal cancers displayed a higher angiogenic score compared to gastric cancers. Conventional therapy induced a striking reduction in the angiogenic score only in rectal cancer patients. Taken together, our findings suggest that the pCLE technology is suitable for the evaluation of the tumor microvasculature abnormalities. Therefore, the real-time assessment of the vasculature status may represent a promising approach to predict the efficacy of the treatments and improve the clinical management of patients with gastric or rectal carcinomas.
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