Evidence map›Paper›PMID 28852099›Full record

ArticleScientific reports2017

Intermolecular base stacking mediates RNA-RNA interaction in a crystal structure of the RNA chaperone Hfq.

Eike C Schulz, Markus Seiler, Cecilia Zuliani, Franka Voigt, Vladimir Rybin, Vivian Pogenberg, Norbert Mücke, Matthias Wilmanns, Toby J Gibson, Orsolya Barabas

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Roquin exhibits opposing effects on RNA stem-loop stability through its two ROQ domain binding sites.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. RNA Granules: A View from the RNA Perspective.Molecules (Basel, Switzerland) · 2020
    Review
  7. Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  8. Article
  9. Small Noncoding Regulatory RNAs fromInternational journal of molecular sciences · 2018
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Eike C SchulzStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117, Heidelberg, Germany.
Markus SeilerStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117, Heidelberg, Germany.
Cecilia ZulianiStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117, Heidelberg, Germany.
Franka VoigtStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117, Heidelberg, Germany.
Vladimir RybinProtein Expression and Purification Core Facility, European Molecular Biology Laboratory, 69117, Heidelberg, Germany.
Vivian PogenbergHamburg Outstation, European Molecular Biology Laboratory, Hamburg, 22603, Germany.ORCID 0000-0002-1021-6804
Norbert MückeDivision Biophysics of Macromolecules, German Cancer Research Center, Heidelberg, 69120, Germany.
Matthias WilmannsHamburg Outstation, European Molecular Biology Laboratory, Hamburg, 22603, Germany.
Toby J GibsonStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117, Heidelberg, Germany.
Orsolya BarabasStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117, Heidelberg, Germany. barabas@embl.de.
European Molecular Biology Laboratory · DEEuropean Molecular Biology Laboratory · DEGerman Cancer Research Center · DEMax Planck Institute for the Structure and Dynamics of Matter · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The RNA-chaperone Hfq catalyses the annealing of bacterial small RNAs (sRNAs) with target mRNAs to regulate gene expression in response to environmental stimuli. Hfq acts on a diverse set of sRNA-mRNA pairs using a variety of different molecular mechanisms. Here, we present an unusual crystal structure showing two Hfq-RNA complexes interacting via their bound RNA molecules. The structure contains two Hfq

Indexed as

Nucleic Acid ConformationAmino Acid MotifsBase SequenceBinding SitesEscherichia coli ProteinsHost Factor 1 ProteinModels, MolecularMolecular StructureProtein BindingRNARNA, MessengerSolutionsStructure-Activity RelationshipEscherichia coli ProteinsHfq protein, E coliHost Factor 1 ProteinRNARNA, MessengerSolutions

Identifiers

PMID28852099
PMCPMC5575007
OpenAlexW2746775195

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.