ArticleScientific reports2017
Unraveling the gut microbiome of the long-lived naked mole-rat.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Could the naked mole-rat become the new standard for studying human gut health and probiotics?The Journal of pathology · 2026Article
- The naked mole-rat microbiome is associated with healthy aging and social structure.Cell reports · 2026Article
- Characterisation of bacteria-induced colitis and its modulation by probiotics in naked mole rats: a new mammalian model for acute inflammatory disease.The Journal of pathology · 2026Article
- Impact of acute and chronic hypoxia on the heme oxygenase/carbon monoxide pathway in naked mole-rats (Heterocephalus glaber).The Journal of experimental biology · 2025Article
- Seasonal Variation in the Diversity of the Gut Microbiota of Short-Faced Moles Reveals the Associations of Climatic Factors on the Gut Microbiota of Subterranean Mammals.Ecology and evolution · 2025Article
- Gut microbiota and healthy longevity.Science China. Life sciences · 2024Review
- What Can the Gut Microbiota of Animals Teach Us about the Relationship between Nutrition and Burden of Lifestyle Diseases?Nutrients · 2024Review
- Structural characteristics of gut microbiota in longevity from Changshou town, Hubei, China.Applied microbiology and biotechnology · 2024Article
- Effects of host identity on the gut microbiota: A comparative study on three microtinae species.Animal models and experimental medicine · 2024Article
- Bacteroidetes to Firmicutes: captivity changes the gut microbiota composition and diversity in a social subterranean rodent.Animal microbiome · 2023Article
- Macrophages from naked mole-rat possess distinct immunometabolic signatures upon polarization.Frontiers in immunology · 2023Article
- Gut microbiota as an antioxidant system in centenarians associated with high antioxidant activities of gut-resident Lactobacillus.NPJ biofilms and microbiomes · 2022Article
- Early Queen Development in Honey Bees: Social Context and Queen Breeder Source Affect Gut Microbiota and Associated Metabolism.Microbiology spectrum · 2022Article
- Deep insights into the gut microbial community of extreme longevity in south Chinese centenarians by ultra-deep metagenomics and large-scale culturomics.NPJ biofilms and microbiomes · 2022Article
- Bacterial microbiome of faecal samples of naked mole-rat collected from the toilet chamber.BMC research notes · 2022Article
- A review of the preclinical and clinical studies on the role of the gut microbiome in aging and neurodegenerative diseases and its modulation.Frontiers in cellular neuroscience · 2022Review
- Gut Microbiome Alterations and Hepatic Metabolic Flexibility in the Gansu Zokor,Frontiers in cardiovascular medicine · 2022Article
- Gut microbiota on admission as predictive biomarker for acute necrotizing pancreatitis.Frontiers in immunology · 2022Article
- Comparative research of intestinal microbiota diversity and body mass regulation inFrontiers in microbiology · 2022Article
- Circulating fatty acids and endocannabinoidome-related mediator profiles associated to human longevity.GeroScience · 2021Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The naked mole-rat (Heterocephalus glaber) is a subterranean mouse-sized African mammal that shows astonishingly few age-related degenerative changes and seems to not be affected by cancer. These features make this wild rodent an excellent model to study the biology of healthy aging and longevity. Here we characterize for the first time the intestinal microbial ecosystem of the naked mole-rat in comparison to humans and other mammals, highlighting peculiarities related to the specific living environment, such as the enrichment in bacteria able to utilize soil sulfate as a terminal electron acceptor to sustain an anaerobic oxidative metabolism. Interestingly, some compositional gut microbiota peculiarities were also shared with human gut microbial ecosystems of centenarians and Hadza hunter-gatherers, considered as models of a healthy gut microbiome and of a homeostatic and highly adaptive gut microbiota-host relationship, respectively. In addition, we found an enrichment of short-chain fatty acids and carbohydrate degradation products in naked mole-rat compared to human samples. These data confirm the importance of the gut microbial ecosystem as an adaptive partner for the mammalian biology and health, independently of the host phylogeny.
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