ArticleScientific reports2017
Connecting individual to collective cell migration.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Protrusion force and cell-cell adhesion-induced polarity alignment govern collective migration modes.Biophysical journal · 2025Article
- Model supports asymmetric regulation across the intercellular junction for collective cell polarization.PLoS computational biology · 2024Article
- COMethods and protocols · 2024Article
- Maximum likelihood phylogeographic inference of cell motility and cell division from spatial lineage tracing data.Bioinformatics (Oxford, England) · 2024Article
- Dynamics of multicellular swirling on micropatterned substrates.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A deep learning-based pipeline for analyzing the influences of interfacial mechanochemical microenvironments on spheroid invasion using differential interference contrast microscopic images.Materials today. Bio · 2023Article
- Large Coherent States Formed from DisorderedEntropy (Basel, Switzerland) · 2023Article
- Engineering tools for quantifying and manipulating forces in epithelia.Biophysics reviews · 2023Review
- Accelerated epithelial layer healing induced by tactile anisotropy in surface topography.Science advances · 2023Article
- Paxillin promotes breast tumor collective cell invasion through maintenance of adherens junction integrity.Molecular biology of the cell · 2022Article
- Disentangling cadherin-mediated cell-cell interactions in collective cancer cell migration.Biophysical journal · 2022Article
- Tunable 3D Hydrogel Microchannel Networks to Study Confined Mammalian Cell Migration.Advanced healthcare materials · 2021Article
- Review
- Roles of leader and follower cells in collective cell migration.Molecular biology of the cell · 2021Review
- Topological data analysis of collective and individual epithelial cells using persistent homology of loops.Soft matter · 2021Article
- Born to Run? Diverse Modes of Epithelial Migration.Frontiers in cell and developmental biology · 2021Review
- Bridging from single to collective cell migration: A review of models and links to experiments.PLoS computational biology · 2020Review
- Article
- Decoding collective communications using information theory tools.Journal of the Royal Society, Interface · 2020Article
- Dancing Styles of Collective Cell Migration: Image-Based Computational Analysis of JRAB/MICAL-L2.Frontiers in cell and developmental biology · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collective cell migration plays a pivotal role in the formation of organs, tissue regeneration, wound healing and many disease processes, including cancer. Despite the considerable existing knowledge on the molecular control of cell movements, it is unclear how the different observed modes of collective migration, especially for small groups of cells, emerge from the known behaviors of individual cells. Here we derive a physical description of collective cellular movements from first principles, while accounting for known phenomenological cell behaviors, such as contact inhibition of locomotion and force-induced cell repolarization. We show that this theoretical description successfully describes the motion of groups of cells of arbitrary numbers, connecting single cell behaviors and parameters (e.g., adhesion and traction forces) to the collective migration of small groups of cells and the expansion of large cell colonies. Specifically, using a common framework, we explain how cells characterized by contact inhibition of locomotion can display coherent collective behavior when in groups, even in the absence of biochemical signaling. We find an optimal group size leading to maximal group persistence and show that cell proliferation prevents the buildup of intercellular forces within cell colonies, enabling their expansion.
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Registered trials
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