ArticleScientific reports2017
Perturbation of formate pathway and NADH pathway acting on the biohydrogen production.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 47 citations in OpenAlex.
- Redox-centric metabolic rewiring for dark-fermentative hydrogen production in Enterobacter aerogenes.Bioprocess and biosystems engineering · 2026Article
- Engineered Clostridium butyricum: a promising application of synthetic biology in comprehensive health.Microbial cell factories · 2025Review
- Biohythane production via anaerobic digestion process: fundamentals, scale-up challenges, and techno-economic and environmental aspects.Environmental science and pollution research international · 2024Review
- Optimization of hydrogen production in Enterobacter aerogenes by Complex I peripheral fragments destruction and maeA overexpression.Microbial cell factories · 2023Article
- Integrated strategy of CRISPR-Cas9 gene editing and small RNA RhyB regulation inBiotechnology notes (Amsterdam, Netherlands) · 2022Article
- Numerical study on the effect of discrete catalytic layer arrangement on methane steam reforming performance.RSC advances · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
The formate pathway and NADH pathway as two common hydrogen-producing metabolic pathways have been well characterized to understand and improve biohydrogen production. These two pathways have been thought to be separate and have been independently investigated. However, in this study, perturbation of genes (hycA, fdhF, fhlA, ldhA, nuoB, hybO, fdh1, narP, and ppk) in Enterobacter aerogenes related to the formate pathway or NADH pathway revealed that these two pathways affected each other. Further metabolic analysis suggested that a linear relationship existed between the relative change of hydrogen yield in the formate pathway or NADH pathway and the relative change of NADH yield or ATP yield. Thus, this finding provides new insight into the role of cellular reducing power and energy level in the hydrogen metabolism. It also establishes a rationale for improving hydrogen production from a global perspective.
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