ArticleScientific reports2017
Comprehensive transcriptome analyses reveal tomato plant responses to tobacco rattle virus-based gene silencing vectors.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Tobacco rattle virus infection alters Arabidopsis gene expression via virus-derived SiRNAs and host MiRNA network disruption.BMC genomics · 2025Article
- Pharmacokinetic Characterization of Single-Stranded DNA in Murine Models Using High-Specific-ActivityACS omega · 2025Article
- Evolutionarily New Solanaceous DCL2 Family Members Acquire Functions in Tomato.Molecular plant pathology · 2025Article
- PhWRKY30 activates salicylic acid biosynthesis to positively regulate antiviral defense response in petunia.Horticulture research · 2025Article
- Article
- Comparative transcriptome analysis of resistant and susceptible watermelon genotypes reveals the role of RNAi, callose, proteinase, and cell wall in squash vein yellowing virus resistance.Frontiers in plant science · 2024Article
- A nuclear import pathway exploited by pathogenic noncoding RNAs.The Plant cell · 2022Article
- Silencing the conserved small nuclear ribonucleoprotein SmD1 target gene alters susceptibility to root-knot nematodes in plants.Plant physiology · 2022Article
- RNA-Based Technologies for Engineering Plant Virus Resistance.Plants (Basel, Switzerland) · 2021Review
- Review
- Comparative Transcriptome Analysis Provides Molecular Insights into the Interaction ofViruses · 2020Article
- Comprehensive transcriptome analysis and functional characterization of PR-5 for its involvement in tomato Sw-7 resistance to tomato spotted wilt tospovirus.Scientific reports · 2019Article
- Virus-induced gene silencing (VIGS) for functional analysis of MYB80 gene involved in Solanum lycopersicum cold tolerance.Protoplasma · 2019Article
- Expanding Alternative Splicing Identification by Integrating Multiple Sources of Transcription Data in Tomato.Frontiers in plant science · 2019Article
- Potato Spindle Tuber Viroid Modulates Its Replication through a Direct Interaction with a Splicing Regulator.Journal of virology · 2018Article
- Enabling the study of gene function in gymnosperms: Virus-induced gene silencing inApplications in plant sciencesArticle
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Authors and funding
4 authors.
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Abstract
In plants, virus-induced gene silencing (VIGS) is a popular tool for functional genomic studies or rapidly assessing individual gene functions. However, molecular details regarding plant responses to viral vectors remain elusive, which may complicate experimental designs and data interpretation. To this end, we documented whole transcriptome changes of tomato elicited by the application of the most widely used tobacco rattle virus (TRV)-based vectors, using comprehensive genome-wide analyses. Our data illustrated multiple biological processes with functional implications, including (1) the enhanced activity of miR167 in guiding the cleavage of an auxin response factor; (2) reduced accumulation of phased secondary small interfering RNAs from two genomic loci; (3) altered expression of ~500 protein-coding transcripts; and (4) twenty long noncoding RNAs specifically responsive to TRV vectors. Importantly, we unraveled large-scale changes in mRNA alternative splicing patterns. These observations will facilitate future application of VIGS vectors for functional studies benefiting the plant research community and help deepen the understanding of plant-virus interactions.
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