Evidence map›Paper›PMID 28852051›Full record

ArticleScientific reports2017

Effective method for drug injection into subcutaneous tissue.

Hyejeong Kim, Hanwook Park, Sang Joon Lee

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06327113 (A Phase 2 Randomized Study Comparing Subcutaneous Tumescent Antibiotic Administration With Standard of Care for the Treatment of Chronic Wounds), which is not on this map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06327113 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

A Phase 2 Randomized Study Comparing Subcutaneous Tumescent Antibiotic Administration With Standard of Care for the Treatment of Chronic Wounds

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2028Enrolled60ConditionsNon-healing WoundArmsCeFAZolin Injectable Solution
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.

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  18. Efficacy and safety of guttiferone E in melanoma-bearing mice.Naunyn-Schmiedeberg's archives of pharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hyejeong KimDepartment of Mechanical Engineering, Pohang University of Science and Technology, Pohang, 37673, Gyeongsangbuk, Republic of Korea.
Hanwook ParkDepartment of Mechanical Engineering, Pohang University of Science and Technology, Pohang, 37673, Gyeongsangbuk, Republic of Korea.
Sang Joon LeeDepartment of Mechanical Engineering, Pohang University of Science and Technology, Pohang, 37673, Gyeongsangbuk, Republic of Korea. sjlee@postech.ac.kr.
Pohang University of Science and Technology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subcutaneous injection of drug solution is widely used for continuous and low dose drug treatment. Although the drug injections have been administered for a long time, challenges in the design of injection devices are still needed to minimize the variability, pain, or skin disorder by repeated drug injections. To avoid these adverse effects, systematic study on the effects of injection conditions should be conducted to improve the predictability of drug effect. Here, the effects of injection conditions on the drug permeation in tissues were investigated using X-ray imaging technique which provides real-time images of drug permeation with high spatial resolution. The shape and concentration distribution of the injected drug solution in the porcine subcutaneous and muscle tissues are visualized. Dynamic movements of the wetting front (WF) and temporal variations of water contents in the two tissues are quantitatively analyzed. Based on the quantitative analysis of the experimental data, the permeability of drug solution through the tissues are estimated according to permeation direction, injection speed, and tissue. The present results would be helpful for improving the performance of drug injection devices and for predicting the drug efficacy in tissues using biomedical simulation.

Indexed as

Drug Delivery SystemsInjections, SubcutaneousAlgorithmsHumansModels, TheoreticalOrgan SpecificityPermeabilitySkin

Identifiers

PMID28852051
PMCPMC5575294
OpenAlexW2750524685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.