ArticleScientific reports2017
Neurotransmitters and neuropeptides in gonadal steroid receptor-expressing cells in medial preoptic area subregions of the male mouse.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
- Single-Nucleus Transcriptomics of the Mouse Medial Preoptic Area Reveals Sex-Dependent Molecular Signatures of Social Dominance.bioRxiv : the preprint server for biology · 2026Article
- Biological Mechanisms Balancing Torpor and Reproduction in Mammals.Endocrinology · 2025Review
- Medial preoptic CCKAR mediates anxiety and aggression induced by chronic emotional stress in male mice.National science review · 2025Article
- The hypothalamic effects of PACAP on the hypothalamic-pituitary-gonadal axis in male mice.Frontiers in endocrinology · 2025Article
- Hormonal Actions in the Medial Preoptic Area Governing Parental Behavior: Novel Insights From New Tools.Endocrinology · 2024Review
- Neurotensin and Its Involvement in Female Hormone-Sensitive Cancers.International journal of molecular sciences · 2024Review
- Activation of lateral preoptic neurons is associated with nest-building in male mice.Scientific reports · 2024Article
- The medial preoptic area and its projections to the ventral tegmental area and the periaqueductal gray are activated in response to social play behavior in juvenile rats.Behavioral neuroscience · 2023Article
- Article
- The medial preoptic area and acute cocaine's stimulant effects in rats: Potential influences of estradiol and biological sex.Hormones and behavior · 2023Article
- Sex Steroid Hormone Receptor Content of Medial Preoptic Efferents to the Ventral Tegmental Area Is Sexually Dimorphic: Implications for Sex Differences in Mesolimbic Reward Processing.Neuroendocrinology · 2023Article
- Neurobiology of Maternal Behavior in Nonhuman Mammals: Acceptance, Recognition, Motivation, and Rejection.Animals : an open access journal from MDPI · 2022Review
- Fluorescence quenching by high-power LEDs for highly sensitive fluorescenceFrontiers in molecular neuroscience · 2022Article
- A Scientometric Approach to Review the Role of the Medial Preoptic Area (MPOA) in Parental Behavior.Brain sciences · 2021Review
- The Role of Reproductive Hormones in Sex Differences in Sleep Homeostasis and Arousal Response in Mice.Frontiers in neuroscience · 2021Article
- Cellular Composition of the Preoptic Area Regulating Sleep, Parental, and Sexual Behavior.Frontiers in neuroscience · 2021Review
- Neural and Hormonal Control of Sexual Behavior.Endocrinology · 2020Review
- ModifiedFrontiers in molecular neuroscience · 2020Article
- The parental brain and behavior: A target for endocrine disruption.Frontiers in neuroendocrinology · 2019Review
- AGRP Neurons Project to the Medial Preoptic Area and Modulate Maternal Nest-Building.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Testosterone is involved in male sexual, parental and aggressive behaviors through the androgen receptor (AR) and estrogen receptor (ER) α expressed in the brain. Although several studies have demonstrated that ERα and AR in the medial preoptic area (MPOA) are required for exhibiting sexual and aggressive behaviors of male mice, the molecular characteristics of ERα- and AR-expressing cells in the mouse MPOA are largely unknown. Here, we performed in situ hybridization for neurotransmitters and neuropeptides, combined with immunohistochemistry for ERα and AR to quantitate and characterize gonadal steroid receptor-expressing cells in the MPOA subregions of male mice. Prodynorphin, preproenkephalin (Penk), cocaine- and amphetamine-related transcript, neurotensin, galanin, tachykinin (Tac)1, Tac2 and thyrotropin releasing hormone (Trh) have distinct expression patterns in the MPOA subregions. Gad67-expressing cells were the most dominant neuronal subtype among the ERα- and AR-expressing cells throughout the MPOA. The percentage of ERα- and AR-immunoreactivities varied depending on the neuronal subtype. A substantial proportion of the neurotensin-, galanin-, Tac2- and Penk-expressing cells in the MPOA were positive for ERα and AR, whereas the vast majority of the Trh-expressing cells were negative. These results suggest that testosterone exerts differential effects depending on both the neuronal subtypes and MPOA subregions.
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