Evidence map›Paper›PMID 28852049›Full record

ArticleScientific reports2017

Nonsteroidal Anti-inflammatory Drug Interaction with Prostacyclin Synthase Protects from Miscarriage.

Digna R Velez Edwards, Todd L Edwards, Michael J Bray, Eric Torstenson, Sarah Jones, Martha J Shrubsole, Harvey J Muff, Katherine E Hartmann

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Digna R Velez EdwardsVanderbilt Epidemiology Center, Vanderbilt University, Nashville, Tennessee, 37203, USA. digna.r.velez.edwards@vanderbilt.edu.
Todd L EdwardsInstitute for Medicine and Public Health, Vanderbilt University, Nashville, Tennessee, 37203, USA.ORCID 0000-0003-4318-6119
Michael J BrayVanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, 37203, USA.
Eric TorstensonVanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, 37203, USA.
Sarah JonesInstitute for Medicine and Public Health, Vanderbilt University, Nashville, Tennessee, 37203, USA.
Martha J ShrubsoleVanderbilt Epidemiology Center, Vanderbilt University, Nashville, Tennessee, 37203, USA.ORCID 0000-0002-5591-7575
Harvey J MuffDivision of Epidemiology, Vanderbilt University, Nashville, Tennessee, 37203, USA.
Katherine E HartmannVanderbilt Epidemiology Center, Vanderbilt University, Nashville, Tennessee, 37203, USA.
Vanderbilt University · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Understanding and Controlling p120 Dysfunction in CRCP50CA095103 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 2002 to 2017
$33.6M
Building Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3M
Consequences and Course of Uterine Fibroids in PregnancyR01HD043883 · NICHD · VANDERBILT UNIVERSITY · PI HARTMANN, KATHERINE E · 2004 to 2008
$3.1M
Training Program on Genetic Variation and Human PhenotypesT32GM080178 · NIGMS · VANDERBILT UNIVERSITY · PI COX, NANCY J, SAMUELS, DAVID C · 2007 to 2021
$3.1M
Genetic and Endocrine Pathways Linking Obesity with Prostate CancerR01CA121060 · NCI · VANDERBILT UNIVERSITY · PI FOWKE, JAY H. · 2007 to 2011
$2.8M
Non-steroidal anti-inflammatory use and miscarriageR01HD049675 · NICHD · VANDERBILT UNIVERSITY · PI HARTMANN, KATHERINE E · 2006 to 2010
$2.6M
Dietary Calcium and Magnesium, Genetics, and Colorectal AdenomaR01AT004660 · NCCIH · VANDERBILT UNIVERSITY · PI DAI, QI · 2008 to 2011
$2.1M
NCATS NIH HHS UL1 TR000445NCCIH NIH HHS R01 AT004660NCI NIH HHS P30 CA068485NCI NIH HHS P50 CA095103NCI NIH HHS R01 CA121060NCRR NIH HHS UL1 RR024975NICHD NIH HHS K12 HD043483NICHD NIH HHS R01 HD043883NICHD NIH HHS R01 HD049675NIGMS NIH HHS T32 GM080178
6 · The paper itself

Abstract

This study evaluates the relationship between single nucleotide polymorphisms (SNPs) in nonsteroidal anti-inflammatory drug (NSAID) metabolism and related pathways and spontaneous abortion (SAB, gestation < 20 weeks) risk. Women were enrolled in Right from the Start (2004-2010) prospective cohort. Periconceptional NSAIDs reported through the sixth week of pregnancy were obtained from study interviews. We evaluated 201 SNPs in 600 European American women. Interaction analyses between NSAID use and SNPs were conducted using logistic regression, adjusted for confounders. We also evaluated prostaglandin E2 urinary metabolite (PGE-M) in an independent population for association with SNPs using linear regression. NSAID use was reported by 63% of cases and 62% controls. The most significant interaction was at prostacyclin synthase (PGIS) rs5602 (OR = 0.34, 95% CI 0.19-0.60, p = 2.45 × 10

Indexed as

Disease SusceptibilityAbortion, SpontaneousAdultAllelesAnti-Inflammatory Agents, Non-SteroidalCytochrome P-450 Enzyme SystemFemaleGenotypeHumansIntramolecular OxidoreductasesOdds RatioPolymorphism, Single NucleotidePregnancyRisk FactorsAnti-Inflammatory Agents, Non-SteroidalCytochrome P-450 Enzyme SystemIntramolecular Oxidoreductasesprostacyclin synthetase

Identifiers

PMID28852049
PMCPMC5575303
OpenAlexW2749859918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.