Evidence map›Paper›PMID 28852048›Full record

ArticleScientific reports2017

Unawareness of Hepatitis B Virus Infection confers on Higher Rate of Metabolic Syndrome: A Community-based Study.

Cheng-Hung Chien, Li-Wei Chen, Chih-Lang Lin, Su-Wie Chang, Yu-Chiau Shyu, Kuan-Fu Chen, Shuo-Wei Chen, Ching-Chih Hu, Chia-Ying Yu, Rong-Nan Chien

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Association between chronic hepatitis B infection and metabolic syndrome.Journal of diabetes and metabolic disorders · 2018
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Cheng-Hung ChienLiver Research Unit, Chang Gung Memorial Hospital, Keelung, Taiwan, R.O.C.ORCID 0000-0001-9596-9209
Li-Wei ChenLiver Research Unit, Chang Gung Memorial Hospital, Keelung, Taiwan, R.O.C.
Chih-Lang LinLiver Research Unit, Chang Gung Memorial Hospital, Keelung, Taiwan, R.O.C.
Su-Wie ChangClinical Informatics and Medical Statistics Research Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan, R.O.C.
Yu-Chiau ShyuCommunity Medicine Research Center, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan, R.O.C.
Kuan-Fu ChenCommunity Medicine Research Center, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan, R.O.C.
Shuo-Wei ChenLiver Research Unit, Chang Gung Memorial Hospital, Keelung, Taiwan, R.O.C.
Ching-Chih HuLiver Research Unit, Chang Gung Memorial Hospital, Keelung, Taiwan, R.O.C.
Chia-Ying YuLiver Research Unit, Chang Gung Memorial Hospital, Keelung, Taiwan, R.O.C.
Rong-Nan ChienLiver Research Unit, Chang Gung Memorial Hospital, Keelung, Taiwan, R.O.C.. ronald@adm.cgmh.org.tw.
Chang Gung Memorial Hospital · TWChang Gung University of Science and Technology · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to determine whether awareness of hepatitis B virus (HBV) serostatus was discordant with metabolic syndrome (MetS) among people with chronic HBV infection. We conducted a community-based study in four Taiwanese districts. A total of 3493 adult participants were recruited. Participants who were hepatitis B surface antigen (HBsAg) seropositive and had self-reported HBV infection were considered aware of hepatitis B (aHB); those who denied a history of HBV infection were considered unaware of hepatitis B (uaHB). Among the 454 participants who were HBsAg seropositive, 275 (60.6%) were aHB and 179 (39.3%) were uaHB. Hypertriglyceridemia showed significant inverse association with HBsAg seropositive, especially among those who were aHB. Insulin resistance was significantly, positively associated with HBsAg seropositive, especially among participants who were uaHB. Those who were uaHB had a higher risk of central obesity, hyperglycemia, insulin resistance, and MetS than those who were aHB (odds ratio = 2.33, 1.64, 2.15, 1.85, respectively, all p < 0.05). The association among the prevalence of MetS, its individual components and HBsAg seropositivity varies according to awareness of HBV infection. It is important to recognize an individual's risk for MetS, especially who were unaware of HBV infection.

Indexed as

AdultAgedBiomarkersComorbidityCross-Sectional StudiesFemaleHepatitis BHepatitis B virusHumansMaleMetabolic SyndromeMiddle AgedOdds RatioPopulation SurveillanceRisk AssessmentRisk FactorsBiomarkers

Identifiers

PMID28852048
PMCPMC5575015
OpenAlexW2745980697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.