Evidence map›Paper›PMID 28852047›Full record

ArticleScientific reports2017

TCA cycle rewiring fosters metabolic adaptation to oxygen restriction in skeletal muscle from rodents and humans.

Daniele Capitanio, Chiara Fania, Enrica Torretta, Agnese Viganò, Manuela Moriggi, Valentina Bravatà, Anna Caretti, Denny Z H Levett, Michael P W Grocott, Michele Samaja and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Signatures of glial activity can be detected in the CSF proteome.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Daniele CapitanioDepartment of Biomedical Sciences for Health, University of Milan, Segrate, (MI), Italy.ORCID 0000-0001-7701-728X
Chiara FaniaUO Proteomica Clinica, IRCCS Policlinico San Donato, San Donato Milanese, (MI), Italy.
Enrica TorrettaDepartment of Biomedical Sciences for Health, University of Milan, Segrate, (MI), Italy.
Agnese ViganòDepartment of Biomedical Sciences for Health, University of Milan, Segrate, (MI), Italy.
Manuela MoriggiCNR-Institute of Bioimaging and Molecular Physiology, Cefalù, (PA) and Segrate, (MI), Italy.
Valentina BravatàCNR-Institute of Bioimaging and Molecular Physiology, Cefalù, (PA) and Segrate, (MI), Italy.
Anna CarettiDepartment of Health Sciences, University of Milan, Milan, Italy.ORCID 0000-0001-6140-6969
Denny Z H LevettCentre for Altitude, Space, and Extreme Environment Medicine, University College London (UCL), Institute of Child Health, University College London, London, UK.
Michael P W GrocottCentre for Altitude, Space, and Extreme Environment Medicine, University College London (UCL), Institute of Child Health, University College London, London, UK.
Michele SamajaDepartment of Health Sciences, University of Milan, Milan, Italy.
Paolo CerretelliCNR-Institute of Bioimaging and Molecular Physiology, Cefalù, (PA) and Segrate, (MI), Italy.
Cecilia GelfiDepartment of Biomedical Sciences for Health, University of Milan, Segrate, (MI), Italy. cecilia.gelfi@unimi.it.ORCID 0000-0002-2996-6912
University of Milan · ITInstitute of Molecular Bioimaging and Physiology · ITUniversity Hospital Southampton NHS Foundation Trust · GBIRCCS Policlinico San Donato · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In mammals, hypoxic stress management is under the control of the Hypoxia Inducible Factors, whose activity depends on the stabilization of their labile α subunit. In particular, the skeletal muscle appears to be able to react to changes in substrates and O

Indexed as

Adaptation, PhysiologicalCitric Acid CycleEnergy MetabolismAnimalsAutophagyBasic Helix-Loop-Helix ProteinsGene ExpressionHexosaminesHumansHypoxia-Inducible Factor 1, alpha SubunitMetabolic Networks and PathwaysModels, BiologicalMuscle, SkeletalOxygenProteomeProteomicsBasic Helix-Loop-Helix ProteinsHexosaminesHypoxia-Inducible Factor 1, alpha SubunitOxygenProteome

Identifiers

PMID28852047
PMCPMC5575144
OpenAlexW2745412995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.