ArticleScientific reports2017
Anesthetic Alterations of Collective Terahertz Oscillations in Tubulin Correlate with Clinical Potency: Implications for Anesthetic Action and Post-Operative Cognitive Dysfunction.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 99 citations in OpenAlex.
- Cellular and Microcircuit Mechanisms of Anesthetic Disruption of Conscious-State Organization.Cells · 2026Review
- The Janus Face of Isoflurane: A Dose-Age-Response Model of Cognitive Impact.Biomolecules · 2026Review
- Neuronal Microtubules and Radiofrequency Waves: The Quantum Core of Human Consciousness, Memory, and Pathway to Memory Enhancement/Recovery.International journal of molecular sciences · 2026Review
- A Unified Model of Consciousness: Glycoprotein Patterns in Memory Processes and Quantum Entanglement.Current medicinal chemistry · 2026Article
- Editorial: Quantum and quantum-like effects across neuroscience.Frontiers in human neuroscience · 2026Article
- Quantum theories of consciousness: a critical review of feasibility, philosophical sufficiency, and empirical testability.Frontiers in psychology · 2026Review
- Self-referential processing as the biological switch between classical and quantum functioning of the brain.Frontiers in human neuroscience · 2026Article
- Microtubule-modulating drugs alter sensitivity to isoflurane in mice.BMC anesthesiology · 2025Article
- A new horizon for neuroscience: terahertz biotechnology in brain research.Neural regeneration research · 2025Article
- A quantum microtubule substrate of consciousness is experimentally supported and solves the binding and epiphenomenalism problems.Neuroscience of consciousness · 2025Article
- Macroscopic quantum effects in the brain: new insights into the fundamental principle underlying conscious processes.Frontiers in human neuroscience · 2025Article
- The quantum-classical complexity of consciousness and orchestrated objective reduction.Frontiers in human neuroscience · 2025Article
- The impact of ketamine and thiopental anesthesia on ultraweak photon emission and oxidative-nitrosative stress in rat brains.Frontiers in systems neuroscience · 2025Article
- Conscious active inference II: Quantum orchestrated objective reduction among intraneuronal microtubules naturally accounts for discrete perceptual cycles.Computational and structural biotechnology journal · 2025Review
- The concept of biophotonic signaling in the human body and brain: rationale, problems and directions.Frontiers in systems neuroscience · 2025Review
- Article
- Anesthesia and the neurobiology of consciousness.Neuron · 2024Review
- Ultra weak photon emission-a brief review.Frontiers in physiology · 2024Review
- Emergence of information processing in biological systems and the origin of life.Communicative & integrative biology · 2024Article
- An In Silico Investigation of the Molecular Interactions between Volatile Anesthetics and Actin.Pharmaceuticals (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anesthesia blocks consciousness and memory while sparing non-conscious brain activities. While the exact mechanisms of anesthetic action are unknown, the Meyer-Overton correlation provides a link between anesthetic potency and solubility in a lipid-like, non-polar medium. Anesthetic action is also related to an anesthetic's hydrophobicity, permanent dipole, and polarizability, and is accepted to occur in lipid-like, non-polar regions within brain proteins. Generally the protein target for anesthetics is assumed to be neuronal membrane receptors and ion channels, however new evidence points to critical effects on intra-neuronal microtubules, a target of interest due to their potential role in post-operative cognitive dysfunction (POCD). Here we use binding site predictions on tubulin, the protein subunit of microtubules, with molecular docking simulations, quantum chemistry calculations, and theoretical modeling of collective dipole interactions in tubulin to investigate the effect of a group of gases including anesthetics, non-anesthetics, and anesthetic/convulsants on tubulin dynamics. We found that these gases alter collective terahertz dipole oscillations in a manner that is correlated with their anesthetic potency. Understanding anesthetic action may help reveal brain mechanisms underlying consciousness, and minimize POCD in the choice and development of anesthetics used during surgeries for patients suffering from neurodegenerative conditions with compromised cytoskeletal microtubules.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.