ArticleScientific reports2017
Linoleic acid metabolite leads to steroid resistant asthma features partially through NF-κB.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- The association of newborn metabolites with early-life wheezing and asthma among US children in the ECHO Program.Communications medicine · 2026Article
- Metabolic effects following initiation of single-inhaler triple therapy in COPD: a prospective observational study.Molecular medicine (Cambridge, Mass.) · 2026Observational
- Obesity: Next game changer of allergic airway diseases?Clinical and translational medicine · 2025Review
- Intranasal dupilumab improves responsiveness to steroid in an asthma mouse model.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- The Octadecanoids: Synthesis and Bioactivity of 18-Carbon Oxygenated Fatty Acids in Mammals, Bacteria, and Fungi.Chemical reviews · 2025Review
- Association between omega-6 fatty acid intake and asthma in US children and adolescents.BMC pediatrics · 2024Article
- The re-emerging role of linoleic acid in paediatric asthma.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- The Role of Systems Biology in Deciphering Asthma Heterogeneity.Life (Basel, Switzerland) · 2022Review
- Microbiome profiling of nasal extracellular vesicles in patients with allergic rhinitis.The World Allergy Organization journal · 2022Article
- Sputum Metabolomic Profiling Reveals Metabolic Pathways and Signatures Associated With Inflammatory Phenotypes in Patients With Asthma.Allergy, asthma & immunology research · 2022Article
- Association of Maternal Erythrocyte PUFA during Pregnancy with Offspring Allergy in the Chinese Population.Nutrients · 2022Article
- Targeted Lipidomics for Characterization of PUFAs and Eicosanoids in Extracellular Vesicles.Nutrients · 2022Article
- Metabolome subtyping of severe bronchiolitis in infancy and risk of childhood asthma.The Journal of allergy and clinical immunology · 2022Article
- The Role of Cytokines in Nephrotic Syndrome.Mediators of inflammation · 2022Review
- Corticosteroid insensitivity persists in the absence of STAT1 signaling in severe allergic airway inflammation.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Potential Metabolic Biomarkers in Adult Asthmatics.Metabolites · 2021Review
- Integrated-omics endotyping of infants with rhinovirus bronchiolitis and risk of childhood asthma.The Journal of allergy and clinical immunology · 2021Article
- Chronic Intermittent Hypoxia Reduces the Effects of Glucosteroid in Asthma via Activating the p38 MAPK Signaling Pathway.Frontiers in physiology · 2021Article
- Long Chain Fatty Acids as Modulators of Immune Cells Function: Contribution of FFA1 and FFA4 Receptors.Frontiers in physiology · 2021Review
- MiRNAs as Novel Adipokines: Obesity-Related Circulating MiRNAs Influence Chemosensitivity in Cancer Patients.Non-coding RNA · 2020Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies have highlighted the role of nutritional and metabolic modulators in asthma pathobiology. Steroid resistance is an important clinical problem in asthma but lacks good experimental models. Linoleic acid, a polyunsaturated fatty acid, has been linked to asthma and glucocorticoid sensitivity. Its 12/15-lipoxygenase metabolite, 13-S-hydroxyoctadecadienoic acid (HODE) induces mitochondrial dysfunction, with severe airway obstruction and neutrophilic airway inflammation. Here we show that HODE administration leads to steroid unresponsiveness in an otherwise steroid responsive model of allergic airway inflammation (AAI). HODE treatment to allergic mice further increased airway hyperresponsiveness and goblet metaplasia. Treatment with dexamethasone was associated with increased neutrophilic inflammation in HODE treated allergic mice; unlike control allergic mice that showed resolution of inflammation. HODE induced loss of steroid sensitivity was associated with increased p-NFkB in mice and reduced GR-α transcript levels in cultured human bronchial epithelia. In summary, HODE modifies typical AAI to recapitulate many of the phenotypic features seen in severe steroid unresponsive asthma. We speculate that since HODE is a natural metabolite, it may be relevant to the increased asthma severity and steroid insensitivity in patients who are obese or consume high fat diets. Further characterization of HODE induced steroid insensitivity may clarify the mechanisms.
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