Evidence map›Paper›PMID 28851949›Full record

ArticleScientific reports2017

Hypertension Susceptibility Loci are Associated with Anthracycline-related Cardiotoxicity in Long-term Childhood Cancer Survivors.

Michelle A T Hildebrandt, Monica Reyes, Xifeng Wu, Xia Pu, Kara A Thompson, Jianzhong Ma, Andrew P Landstrom, Alanna C Morrison, Joann L Ater

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
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  8. Article
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  11. Anthracycline Toxicity: Light at the End of the Tunnel?Annual review of pharmacology and toxicology · 2024
    Review
  12. Review
  13. Article
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  16. Review
  17. Article
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  19. Frailty and aging in cancer survivors.Translational research : the journal of laboratory and clinical medicine · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Michelle A T HildebrandtDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. mhildebr@mdanderson.org.
Monica ReyesDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Xifeng WuDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Xia PuDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Kara A ThompsonDepartment of Cardiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Jianzhong MaDepartment of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas, USA.
Andrew P LandstromSection of Cardiology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-1878-9631
Alanna C MorrisonDepartment of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas, USA.
Joann L AterDivision of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
The University of Texas MD Anderson Cancer Center · USThe University of Texas Health Science Center at Houston · USBaylor College of Medicine · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

Anthracycline-based chemotherapy is associated with dose-dependent, irreversible damage to the heart. Childhood cancer survivors with hypertension after anthracycline exposure are at increased risk of cardiotoxicity, leading to the hypothesis that genetic susceptibility loci for hypertension may serve as predictors for development of late cardiotoxicity. Therefore, we determined the association between 12 GWAS-identified hypertension-susceptibility loci and cardiotoxicity in a cohort of long-term childhood cancer survivors (N = 108) who received anthracyclines and were screened for cardiac function via echocardiograms. Hypertension-susceptibility alleles of PLCE1:rs9327264 and ATP2B1:rs17249754 were significantly associated with cardiotoxicity risk conferring a protective effect with a 64% (95% CI: 0.18-0.76, P = 0.0068) and 74% (95% CI: 0.07-0.96, P = 0.040) reduction in risk, respectively. In RNAseq experiments of human induced pluripotent stem cell (iPSC) derived cardiomyocytes treated with doxorubicin, both PLCE1 and ATP2B1 displayed anthracycline-dependent gene expression profiles. In silico functional assessment further supported this relationship - rs9327264 in PLCE1 (P = 0.0080) and ATP2B1 expression (P = 0.0079) were both significantly associated with daunorubicin IC

Indexed as

Cancer SurvivorsQuantitative Trait LociAnthracyclinesCardiotoxicityCase-Control StudiesChildChild, PreschoolDisease SusceptibilityFemaleFollow-Up StudiesGene Expression ProfilingGenetic VariationHumansHypertensionMaleNeoplasmsAnthracyclines

Identifiers

PMID28851949
PMCPMC5575079
OpenAlexW2746623871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.