ArticleScientific reports2017
Genomic plasticity and rapid host switching can promote the evolution of generalism: a case study in the zoonotic pathogen Campylobacter.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- AcceleratingProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cross-Host Adaptation ofMicroorganisms · 2026Article
- Increased host diversity limits bacterial generalism but may promote microbe-microbe interactions.ISME communications · 2025Article
- New Campylobacter Lineages in New Zealand Freshwater: Pathogenesis and Public Health Implications.Environmental microbiology · 2024Article
- Comparative genomics and virulence potential of Campylobacter coli strains isolated from different sources over 25 years in Brazil.BMC microbiology · 2024Article
- Activation of the l-fucose utilization cluster inHeliyon · 2024Article
- Use of whole genome sequencing for surveillance and control of foodborne diseases:Frontiers in microbiology · 2024Review
- Kinetic, genomic, and physiological analysis reveals diversity in the ecological adaptation and metabolic potential ofMicrobiology spectrum · 2023Article
- Whole-genome-based characterization ofMicrobial genomics · 2023Article
- Genomic insights into zoonotic transmission and antimicrobial resistance in Campylobacter jejuni from farm to fork: a one health perspective.Gut pathogens · 2022Review
- Source Attribution of Human Campylobacteriosis Using Whole-Genome Sequencing Data and Network Analysis.Pathogens (Basel, Switzerland) · 2022Article
- Agents of Campylobacteriosis in Different Meat Matrices in Brazil.International journal of environmental research and public health · 2022Article
- Article
- Quantitative detection and genetic characterization of thermotolerantFrontiers in microbiology · 2022Article
- Characterization ofFrontiers in cellular and infection microbiology · 2022Article
- Zoonotic Transmission ofFrontiers in microbiology · 2022Article
- Isolation and Characterization of Human Intestinal BacteriaFrontiers in microbiology · 2022Article
- Machine learning to predict the source of campylobacteriosis using whole genome data.PLoS genetics · 2021Article
- Genomic Epidemiology and Evolution of Diverse Lineages of Clinical Campylobacter jejuni Cocirculating in New Hampshire, USA, 2017.Journal of clinical microbiology · 2020Article
- Agricultural intensification and the evolution of host specialism in the enteric pathogenProceedings of the National Academy of Sciences of the United States of America · 2020Article
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7 authors.
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Abstract
Horizontal gene transfer accelerates bacterial adaptation to novel environments, allowing selection to act on genes that have evolved in multiple genetic backgrounds. This can lead to ecological specialization. However, little is known about how zoonotic bacteria maintain the ability to colonize multiple hosts whilst competing with specialists in the same niche. Here we develop a stochastic evolutionary model and show how genetic transfer of host segregating alleles, distributed as predicted for niche specifying genes, and the opportunity for host transition could interact to promote the emergence of host generalist lineages of the zoonotic bacterium Campylobacter. Using a modelling approach we show that increasing levels of homologous recombination enhance the efficiency with which selection can fix combinations of beneficial alleles, speeding adaptation. We then show how these predictions change in a multi-host system, with low levels of recombination, consistent with real r/m estimates, increasing the standing variation in the population, allowing a more effective response to changes in the selective landscape. Our analysis explains how observed gradients of host specialism and generalism can evolve in a multihost system through the transfer of ecologically important loci among coexisting strains.
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