ArticleScientific reports2017
Association of monoamine oxidase-A genetic variants and amygdala morphology in violent offenders with antisocial personality disorder and high psychopathic traits.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- The analysis of the prefrontal cortex and its facilitator role of violence: conclusions of a systematic review and meta-analysis based on neuroimaging results.Brain imaging and behavior · 2026Pooled it
- Psychopathy and medial frontal cortex: A systematic review reveals predominantly null relationships.Neuroscience and biobehavioral reviews · 2024Pooled it
- Is the Psychopathic Brain an Artifact of Coding Bias? A Systematic Review.Frontiers in psychology · 2021Pooled it
- Noninvasive Suppression of Responses to Threat Using Focused Ultrasonic Waves.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Type A monoamine oxidase; its unique role in mood, behavior and neurodegeneration.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Deficits in emotion recognition and processing in children with high callous-unemotional traits: the role of the MAOA gene.European child & adolescent psychiatry · 2024Article
- Neurobiology of Aggression-Review of Recent Findings and Relationship with Alcohol and Trauma.Biology · 2023Review
- The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men.Progress in neurobiology · 2020Review
- Are Owls and Larks Different When it Comes to Aggression? Genetics, Neurobiology, and Behavior.Frontiers in behavioral neuroscience · 2020Article
- Beyond Emotions: Oscillations of the Amygdala and Their Implications for Electrical Neuromodulation.Frontiers in neuroscience · 2019Review
- Association of MAOA genetic variants and resilience with psychosocial stress: A longitudinal study of Syrian refugees.PloS one · 2019Article
- Corticostriatal Connectivity in Antisocial Personality Disorder by MAO-A Genotype and Its Relationship to Aggressive Behavior.The international journal of neuropsychopharmacology · 2018Article
- Correlates of Aggression in Personality Disorders: an Update.Current psychiatry reports · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Violent offending is elevated among individuals with antisocial personality disorder (ASPD) and high psychopathic traits (PP). Morphological abnormalities of the amygdala and orbitofrontal cortex (OFC) are present in violent offenders, which may relate to the violence enacted by ASPD + PP. Among healthy males, monoamine oxidase-A (MAO-A) genetic variants linked to low in vitro transcription (MAOA-L) are associated with structural abnormalities of the amygdala and OFC. However, it is currently unknown whether amygdala and OFC morphology in ASPD relate to MAO-A genetic polymorphisms. We studied 18 ASPD males with a history of violent offending and 20 healthy male controls. Genomic DNA was extracted from peripheral leukocytes to determine MAO-A genetic polymorphisms. Subjects underwent a T1-weighted MRI anatomical brain scan that provided vertex-wise measures of amygdala shape and surface area and OFC cortical thickness. We found that ASPD + PP subjects with MAOA-L exhibited decreased surface area in the right basolateral amygdala nucleus and increased surface area in the right anterior cortical amygdaloid nucleus versus healthy MAOA-L carriers. This study is the first to describe genotype-related morphological differences of the amygdala in a population marked by high aggression. Deficits in emotional regulation that contribute to the violence of ASPD + PP may relate to morphological changes of the amygdala under genetic control.
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