ArticleNature communications2017
VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis.
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Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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81citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
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Who cites it
81 citing papers in PubMed, 123 citations in OpenAlex.
- Cardiac rehabilitation may influence leptin and VEGF A crosstalk in patients after acute coronary syndrome.Scientific reports · 2022Trial
- Spatially guided in vivo single-cell functional genomics of postnatal heart.Nature cardiovascular research · 2026Article
- PCSK5 promotes angiogenesis and cardiac repair after myocardial infarction.Nature communications · 2026Article
- Hepatocyte-derived LRG1 primes the liver for metastasis and impairs immunotherapy.Cellular & molecular immunology · 2026Article
- PRINCIPLES GOVERNING ENDOTHELIAL CAVEOLAE ORGANIZATION DURING ANGIOGENESIS.bioRxiv : the preprint server for biology · 2026Article
- Unraveling the VEGF-ETS1 axis: a transcriptomic and single-cell analysis of angiogenesis in endometriosis.Journal of assisted reproduction and genetics · 2026Article
- Identification of Skin Multicellular Reprogramming Factors as Potential Treatment for Nonhealing Diabetic Foot Ulcers.Advances in wound care · 2026Article
- Unraveling the VEGF-ETS1 axis: a transcriptomic and single-cell analysis of angiogenesis in endometriosis.Journal of assisted reproduction and genetics · 2026Article
- Ets1-regulated endothelial-secreted factors promote compact myocardial growth and contribute to the pathogenesis of ventricular non-compaction.Cardiovascular research · 2026Article
- Lymphatic Endothelial C-C Motif Chemokine Ligand 2 Enhances Lymphangiogenesis and Lymphatic Clearance of Macrophages Following Myocardial Infarction.Journal of the American Heart Association · 2026Article
- Neutrophil Extracellular Traps-Mediated Intraplaque Angiogenesis and Microvascular Permeability Promote Rapid Plaque Progression following Myocardial Infarction.Research (Washington, D.C.) · 2026Article
- Melatonin Suppresses NLRP3 Inflammasome Activation via SIRT1-Mediated ETS1 Deacetylation to Attenuate LPS-Induced Pyroptosis in Alveolar Epithelial Cells.Journal of inflammation research · 2026Article
- ETS1 Promotes Aerobic Glycolysis and Growth in Head and Neck Squamous Cell Carcinoma by Targeting RRAS2.Biochemical genetics · 2025Article
- Transcriptional pause release at enhancers mediates cell identity.NAR cancer · 2025Review
- Fatty acid synthesis promotes mtDNA release via ETS1-mediated oligomerization of VDAC1 facilitating endothelial dysfunction in sepsis-induced lung injury.Cell death and differentiation · 2025Article
- High-intensity interval training improves cognitive dysfunction in chronically stressed mice through alleviating homocysteine-induced transcriptional repression ofNeurobiology of stress · 2025Article
- Bletilla striata polysaccharide microneedles with astragaloside Ⅳ loaded ZIF-8 nanoparticles for wound healing and anti-scar treatment.Journal of nanobiotechnology · 2025Article
- Epigenetic Dysregulation in Cancer: Implications for Gene Expression and DNA Repair-Associated Pathways.International journal of molecular sciences · 2025Review
- Regulatory feedback between VEGF and ERK pathways controls tip-cell expression during sea urchin skeletogenesis.Development (Cambridge, England) · 2025Article
- The Transcriptomic Signature of Donkey Ovarian Tissue Revealed by Cross-Species Comparative Analysis at Single-Cell Resolution.Animals : an open access journal from MDPI · 2025Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors at 3 institutions in 2 countries.
Jiahuan ChenKey Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Yi FuKey Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Daniel S DayDepartment for Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA.
Ye SunDepartment of Ophthalmology, Harvard Medical School/Children's Hospital Boston, Boston, MA, 02115, USA.ORCID http://orcid.org/0000-0002-7674-9056
Shiyan WangKey Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Xiaodong LiangKey Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Fei GuDepartment of Cardiology, Boston Children's Hospital, Boston, MA, 02115, USA.
Fang ZhangKey Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Sean M StevensDepartment of Cardiology, Boston Children's Hospital, Boston, MA, 02115, USA.
Pingzhu ZhouDepartment of Cardiology, Boston Children's Hospital, Boston, MA, 02115, USA.
Kai LiDepartment of Cardiology, Boston Children's Hospital, Boston, MA, 02115, USA.
Yan ZhangRenji-Med Clinical Stem Cell Research Center, Renji Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200127, China.
Ruei-Zeng LinDepartment of Cardiac Surgery, Children's Hospital Boston, Boston, MA, 02115, USA.
Lois E H SmithDepartment of Ophthalmology, Harvard Medical School/Children's Hospital Boston, Boston, MA, 02115, USA.
Jin ZhangDepartment of Cardiology, Boston Children's Hospital, Boston, MA, 02115, USA.
Kun SunDepartment of Pediatric Cardiology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Juan M Melero-MartinDepartment of Cardiac Surgery, Children's Hospital Boston, Boston, MA, 02115, USA.
Zeguang HanKey Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Peter J ParkDepartment for Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA.ORCID http://orcid.org/0000-0001-9378-960X
Bing ZhangKey Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China. bingzhang@sjtu.edu.cn.
William T PuDepartment of Cardiology, Boston Children's Hospital, Boston, MA, 02115, USA. wpu@pulab.org.
Boston Children's Hospital · USShanghai Jiao Tong University · CNBoston University · US
Funding
Administrative Coordinating Center: Cardiovascular Development and Pediatric Cardiac Genomics ConsortiaU01HL131003 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CNOTA, JAMES, OLLBERDING, NICHOLAS J · 2016 to 2024
$54.8MSYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2MRESEARCH METHODS IN PEDIATRICS HEART DISEASET32HL007572 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI Sarah D DE FERRANTI, Jane W. Newburger · 1985 to 2026
$13.0MDietary control of angiogenesis in retinopathy modelsR01EY017017 · NEI · BOSTON CHILDREN'S HOSPITAL · PI Zhongjie Fu, Lois Smith · 2006 to 2026
$11.8MNovel therapies to inhibit Diabetic RetinopathyR24EY024864 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KERN, TIMOTHY S · 2015 to 2019
$8.1MMouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2MRegulation of Cardiac Development in Health and DiseaseUM1HL098166 · NHLBI · HARVARD MEDICAL SCHOOL · PI PENNACCHIO, LEN ALEXANDER, PU, WILLIAM TSWENCHING · 2015 to 2019
$4.4MNEI NIH HHS R01 EY017017NEI NIH HHS R24 EY024864NHLBI NIH HHS T32 HL007572NHLBI NIH HHS U01 HL131003NHLBI NIH HHS UM1 HL098166NICHD NIH HHS P30 HD018655NICHD NIH HHS U54 HD090255
Abstract
Release of promoter-proximally paused RNA polymerase II (RNAPII) is a recently recognized transcriptional regulatory checkpoint. The biological roles of RNAPII pause release and the mechanisms by which extracellular signals control it are incompletely understood. Here we show that VEGF stimulates RNAPII pause release by stimulating acetylation of ETS1, a master endothelial cell transcriptional regulator. In endothelial cells, ETS1 binds transcribed gene promoters and stimulates their expression by broadly increasing RNAPII pause release.
Indexed as
Neovascularization, PathologicAcetylationAnimalsBromodomain Containing ProteinsCell Cycle ProteinsCell MovementChromatinEndothelial CellsExtracellular MatrixFemaleHumansHuman Umbilical Vein Endothelial CellsMaleMiceMice, Inbred C57BLMice, NudeBRD4 protein, humanBrd4 protein, mouseBromodomain Containing ProteinsCell Cycle ProteinsChromatinETS1 protein, humanEts1 protein, mouseNuclear ProteinsProto-Oncogene Protein c-ets-1RNA Polymerase IIRNA, Small InterferingTranscription FactorsVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseVEGFA protein, human
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