ArticleMolecular cancer research : MCR2017
FOXD3 Regulates CSC Marker, DCLK1-S, and Invasive Potential: Prognostic Implications in Colon Cancer.
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Article in Molecular cancer research : MCR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
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Who cites it
26 citing papers in PubMed, 36 citations in OpenAlex.
- DCLK1 regulates stemness and IL-6/STAT3-dependent metastatic niche formation in chemoresistant ovarian cancer.Journal of experimental & clinical cancer research : CR · 2026Article
- miR-136-5p Preferentially Suppresses Cancer Stem-like Cells in Pancreatic Cancer.International journal of molecular sciences · 2026Article
- Hypoxic stimulation of DCLK1 transcription and alternative-promoter switching fuels tumor malignancy in clear cell renal cell carcinoma.Cell death & disease · 2025Article
- DCLK1 isoform (DCLK1-S) as a critical player in promoting inflammation, tissue remodeling, and EMT in mouse models of colitis.PLoS pathogens · 2025Article
- Osteocalcin induces phosphorylation of FOXO1 in human beta-cells and restores insulin expression under hyperglycemic conditions.Research square · 2025Article
- FOXD3 promotes homologous recombination repair and genomic stability by facilitating MRE11-mediated DNA end resection.Acta biochimica et biophysica Sinica · 2025Article
- Clinical significance of "S" isoform of DCLK1 in different gastric cancer subtypes using newly produced monoclonal antibody.Cancer biomarkers : section A of Disease markers · 2025Article
- The epigenetic landscape in intestinal stem cells and its deregulation in colorectal cancer.Stem cells (Dayton, Ohio) · 2024Review
- Isolating Circulating Cancer Stem Cells (CCSCs) from Human Whole Blood.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Epigenetic Landscape and Therapeutic Implication of Gene Isoforms of Doublecortin-Like Kinase 1 for Cancer Stem Cells.International journal of molecular sciences · 2023Review
- Structure-Guided Prediction of the Functional Impact of DCLK1 Mutations on Tumorigenesis.Biomedicines · 2023Review
- Oncogenic functions and clinical significances of DCLK1 isoforms in colorectal cancer: a systematic review and meta-analysis.Cancer cell international · 2022Review
- Targeting DCLK1 overcomes 5-fluorouracil resistance in colorectal cancer through inhibiting CCAR1/β-catenin pathway-mediated cancer stemness.Clinical and translational medicine · 2022Article
- Functional assessment of miR‑1291 in colon cancer cells.International journal of oncology · 2022Article
- ASMdb: a comprehensive database for allele-specific DNA methylation in diverse organisms.Nucleic acids research · 2022Article
- Pleiotropic effects of DCLK1 in cancer and cancer stem cells.Frontiers in molecular biosciences · 2022Review
- DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis.Theranostics · 2022Article
- Cytoplasmic expression of DCLK1-S, a novel DCLK1 isoform, is associated with tumor aggressiveness and worse disease-specific survival in colorectal cancer.Cancer biomarkers : section A of Disease markers · 2022Article
- DCLK1 and its interaction partners: An effective therapeutic target for colorectal cancer.Oncology letters · 2021Review
- DCLK1 isoforms and aberrant Notch signaling in the regulation of human and murine colitis.Cell death discovery · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Shubhashish SarkarDepartment of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas.
Malaney R O'ConnellDepartment of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas.
Yoshinaga OkugawaGastrointestinal Cancer Research Laboratory, Division of Gastroenterology, Department of Internal Medicine, Charles A. Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas.
Brian S LeeMedical School, University of Texas Medical Branch, Galveston, Texas.
Yuji ToiyamaDepartment of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie, Japan.
Masato KusunokiDepartment of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie, Japan.
Robert D DabovalMedical School, University of Texas Medical Branch, Galveston, Texas.
Ajay GoelGastrointestinal Cancer Research Laboratory, Division of Gastroenterology, Department of Internal Medicine, Charles A. Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas.
Pomila SinghDepartment of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas. posingh@utmb.edu.
The University of Texas Medical Branch at Galveston · USMie University · JPBaylor University Medical Center · US
Funding
The Biology and Diagnosis of HNPCCR01CA072851 · NCI · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI GOEL, AJAY · 1996 to 2019
$6.6MRole of Annexin-II in growth factor/co-carcinogenic effects of progastrinR01CA097959 · NCI · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI SINGH, POMILA · 2003 to 2015
$3.7MMETHYLATION BIOMARKER DEVELOPMENT FOR NONINVASIVE DETECTION OF COLORECTAL CANCERR01CA181572 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI GOEL, AJAY · 2014 to 2018
$1.6MNCI NIH HHS R01 CA072851NCI NIH HHS R01 CA097959NCI NIH HHS R01 CA181572
Abstract
The 5' (α)-promoter of the human doublecortin-like kinase 1 (
Indexed as
AgedCarcinogenesisColonic NeoplasmsDNA MethylationDoublecortin-Like KinasesEpigenesis, GeneticFemaleForkhead Transcription FactorsGene Expression Regulation, NeoplasticHCT116 CellsHumansIntracellular Signaling Peptides and ProteinsMaleMiddle AgedNeoplasm InvasivenessPromoter Regions, GeneticDCLK1 protein, humanDoublecortin-Like KinasesForkhead Transcription FactorsFOXD3 protein, humanIntracellular Signaling Peptides and ProteinsProtein IsoformsProtein Serine-Threonine Kinases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.