ArticleCirculation research2017
MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair After Myocardial Ischemia Reperfusion Injury.
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Article in Circulation research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers, 1 of them a synthesis that pooled it.
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159citing papers in PubMed, 1 pooled it
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Who cites it
159 citing papers in PubMed, 1 synthesis or guideline pooled it, 234 citations in OpenAlex.
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- Macrophage efferocytosis in cardiovascular disease: mechanisms and therapeutic implications.ImmunoHorizons · 2026Review
- More Than a Cleanup Crew: The Expanding Biology of Efferocytosis.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- PM2.5 as a driver of human health disorders: insights from the regulated cell death pathways.Military Medical Research · 2026Review
- The immune-cardiovascular metabolic circuitry in myocardial ischemia-reperfusion injury: from metabolic signal release to spatiotemporal reprogramming.Frontiers in immunology · 2026Review
- Efferocytosis in myocardial infarction: the regulatory core from inflammation resolution to cardiac repair.Frontiers in immunology · 2026Review
99 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 1 institution in 1 country.
Matthew DeBergeFrom the Department of Pathology and Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL (M.D., X.Y.Y., S.D., S.Z., L.G., S.M., D.P., X.Z., D.C.Le., W.A.M., X.L., E.B.T.); Division of Molecular Medicine at Columbia University, New York (I.T.); and Department of Immunobiology, School of Medicine, Yale University (C.R.).
Xin Yi YeapFrom the Department of Pathology and Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL (M.D., X.Y.Y., S.D., S.Z., L.G., S.M., D.P., X.Z., D.C.Le., W.A.M., X.L., E.B.T.); Division of Molecular Medicine at Columbia University, New York (I.T.); and Department of Immunobiology, School of Medicine, Yale University (C.R.).
Shirley DehnFrom the Department of Pathology and Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL (M.D., X.Y.Y., S.D., S.Z., L.G., S.M., D.P., X.Z., D.C.Le., W.A.M., X.L., E.B.T.); Division of Molecular Medicine at Columbia University, New York (I.T.); and Department of Immunobiology, School of Medicine, Yale University (C.R.).
Shuang ZhangFrom the Department of Pathology and Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL (M.D., X.Y.Y., S.D., S.Z., L.G., S.M., D.P., X.Z., D.C.Le., W.A.M., X.L., E.B.T.); Division of Molecular Medicine at Columbia University, New York (I.T.); and Department of Immunobiology, School of Medicine, Yale University (C.R.).
Lubov GrigoryevaFrom the Department of Pathology and Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL (M.D., X.Y.Y., S.D., S.Z., L.G., S.M., D.P., X.Z., D.C.Le., W.A.M., X.L., E.B.T.); Division of Molecular Medicine at Columbia University, New York (I.T.); and Department of Immunobiology, School of Medicine, Yale University (C.R.).
Sol MisenerFrom the Department of Pathology and Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL (M.D., X.Y.Y., S.D., S.Z., L.G., S.M., D.P., X.Z., D.C.Le., W.A.M., X.L., E.B.T.); Division of Molecular Medicine at Columbia University, New York (I.T.); and Department of Immunobiology, School of Medicine, Yale University (C.R.).
Daniel ProcissiFrom the Department of Pathology and Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL (M.D., X.Y.Y., S.D., S.Z., L.G., S.M., D.P., X.Z., D.C.Le., W.A.M., X.L., E.B.T.); Division of Molecular Medicine at Columbia University, New York (I.T.); and Department of Immunobiology, School of Medicine, Yale University (C.R.).
Xin ZhouFrom the Department of Pathology and Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL (M.D., X.Y.Y., S.D., S.Z., L.G., S.M., D.P., X.Z., D.C.Le., W.A.M., X.L., E.B.T.); Division of Molecular Medicine at Columbia University, New York (I.T.); and Department of Immunobiology, School of Medicine, Yale University (C.R.).
Daniel C LeeFrom the Department of Pathology and Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL (M.D., X.Y.Y., S.D., S.Z., L.G., S.M., D.P., X.Z., D.C.Le., W.A.M., X.L., E.B.T.); Division of Molecular Medicine at Columbia University, New York (I.T.); and Department of Immunobiology, School of Medicine, Yale University (C.R.).
William A MullerFrom the Department of Pathology and Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL (M.D., X.Y.Y., S.D., S.Z., L.G., S.M., D.P., X.Z., D.C.Le., W.A.M., X.L., E.B.T.); Division of Molecular Medicine at Columbia University, New York (I.T.); and Department of Immunobiology, School of Medicine, Yale University (C.R.).
Xunrong LuoFrom the Department of Pathology and Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL (M.D., X.Y.Y., S.D., S.Z., L.G., S.M., D.P., X.Z., D.C.Le., W.A.M., X.L., E.B.T.); Division of Molecular Medicine at Columbia University, New York (I.T.); and Department of Immunobiology, School of Medicine, Yale University (C.R.).
Carla RothlinFrom the Department of Pathology and Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL (M.D., X.Y.Y., S.D., S.Z., L.G., S.M., D.P., X.Z., D.C.Le., W.A.M., X.L., E.B.T.); Division of Molecular Medicine at Columbia University, New York (I.T.); and Department of Immunobiology, School of Medicine, Yale University (C.R.).
Ira TabasFrom the Department of Pathology and Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL (M.D., X.Y.Y., S.D., S.Z., L.G., S.M., D.P., X.Z., D.C.Le., W.A.M., X.L., E.B.T.); Division of Molecular Medicine at Columbia University, New York (I.T.); and Department of Immunobiology, School of Medicine, Yale University (C.R.).
Edward B ThorpFrom the Department of Pathology and Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL (M.D., X.Y.Y., S.D., S.Z., L.G., S.M., D.P., X.Z., D.C.Le., W.A.M., X.L., E.B.T.); Division of Molecular Medicine at Columbia University, New York (I.T.); and Department of Immunobiology, School of Medicine, Yale University (C.R.). ebthorp@northwestern.edu.
Columbia University · US
Funding
Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8MCELLULAR &MOLECULAR BASIS OF DISEASE TRAINING PROGRAMT32GM008061 · NIGMS · NORTHWESTERN UNIVERSITY · PI CARTHEW, RICHARD W. · 1985 to 2022
$17.1MTWO NOVEL VASCULAR ADHESION MOLECULES: PECAM AND HEC-1R01HL046849 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MULLER, WILLIAM A · 1991 to 2019
$6.7MMentoring For Success: Developing Fundamental Skills For Biomedical ResearchR25GM079300 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MCGEE, RICHARD · 2007 to 2020
$6.6MThe Unfolded Protein Response in Sterol CytoxicityR01HL075662 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TABAS, IRA A · 2004 to 2017
$5.6MEfferocytosis-Directed Inflammation Resolution and Repair in the Hypoxic HeartR01HL122309 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI THORP, EDWARD BENJAMIN · 2014 to 2024
$5.0MTAM receptor tyrosine kinases in inflammatory boweldiseaseR01AI089824 · NIAID · YALE UNIVERSITY · PI ROTHLIN, CARLA · 2010 to 2018
$3.9M PECAM-INDEPENDENT TRANSENDOTHELIAL MIGRATIONR01HL064774 · NHLBI · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI MULLER, WILLIAM A · 2000 to 2020
$3.3MEnhancing Inflammation Resolution in Atherosclerosis via Targeted Nanoparticle-Mediated Delivery of BiologicsR01HL127464 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHI, JINJUN, TABAS, IRA A · 2016 to 2019
$3.0M"MerTK Cleavage and Signaling in Atherosclerosis"R01HL132412 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TABAS, IRA A · 2016 to 2018
$1.5MEfferocytosis Regulation by Hypoxia and Reperfusion After Myocardial InfarctionF32HL127958 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DEBERGE, MATTHEW P · 2015 to 2017
$173kNCATS NIH HHS UL1 TR001422NHLBI NIH HHS F32 HL127958NHLBI NIH HHS R01 HL046849NHLBI NIH HHS R01 HL064774NHLBI NIH HHS R01 HL075662NHLBI NIH HHS R01 HL122309NHLBI NIH HHS R01 HL127464NHLBI NIH HHS R01 HL132412NIAID NIH HHS R01 AI089824NIGMS NIH HHS R25 GM079300NIGMS NIH HHS T32 GM008061
Abstract
rationaleClinical benefits of reperfusion after myocardial infarction are offset by maladaptive innate immune cell function, and therapeutic interventions are lacking.
objectiveWe sought to test the significance of phagocytic clearance by resident and recruited phagocytes after myocardial ischemia reperfusion. METHODS AND
resultsIn humans, we discovered that clinical reperfusion after myocardial infarction led to significant elevation of the soluble form of MerTK (myeloid-epithelial-reproductive tyrosine kinase; ie, soluble MER), a critical biomarker of compromised phagocytosis by innate macrophages. In reperfused mice, macrophage
conclusionsOur data implicate monocyte-induced MerTK cleavage on proreparative MHCII
Indexed as
AnimalsApoptosisc-Mer Tyrosine KinaseCytokinesDisease Models, AnimalFemaleGenetic Predisposition to DiseaseHistocompatibility Antigens Class IIHumansImmunity, InnateMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutMiddle AgedCcr2 protein, mousec-Mer Tyrosine KinaseCytokinesHistocompatibility Antigens Class IIMERTK protein, humanMertk protein, mouseProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesReceptors, CCR2efferocytosisinflammationischemia reperfusion injurymacrophagephagocytosis
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