Evidence map›Paper›PMID 28851751›Full record

ArticleRNA (New York, N.Y.)2017

mRNA pseudouridylation affects RNA metabolism in the parasite

Margaret A Nakamoto, Alexander F Lovejoy, Alicja M Cygan, John C Boothroyd

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Gene regulation inCurrent research in parasitology & vector-borne diseases · 2025
    Article
  10. Quantitative mapping of pseudouridines in bacteria RNA.bioRxiv : the preprint server for biology · 2024
    Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Pseudouridine andRSC chemical biology · 2024
    Review
  17. New directions for Ψ and mRNA (New York, N.Y.) · 2024
    Article
  18. Review
  19. Regulation and functions of non-mNature reviews. Molecular cell biology · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Margaret A NakamotoDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA.
Alexander F LovejoyDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA.
Alicja M CyganDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA.
John C BoothroydDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA jboothr@stanford.edu.
Stanford University · US

Funding

MOLECULAR BASIS OF HOST-PARASITE INTERACTIONT32AI007328 · NIAID · STANFORD UNIVERSITY · PI JUSTIN L SONNENBURG · 1987 to 2026
$11.9M
Role of Pseudouridylation in Toxoplasma DifferentiationR21AI120476 · NIAID · STANFORD UNIVERSITY · PI BOOTHROYD, JOHN C · 2015 to 2016
$441k
NIAID NIH HHS R21 AI120476
6 · The paper itself

Abstract

RNA contains over 100 modified nucleotides that are created post-transcriptionally, among which pseudouridine (Ψ) is one of the most abundant. Although it was one of the first modifications discovered, the biological role of this modification is still not fully understood. Recently, we reported that a pseudouridine synthase (TgPUS1) is necessary for differentiation of the single-celled eukaryotic parasite

Indexed as

RNA Processing, Post-TranscriptionalCells, CulturedFibroblastsHigh-Throughput Nucleotide SequencingHumansPseudouridineRNA, MessengerRNA, ProtozoanRNA, RibosomalToxoplasmaToxoplasmosisPseudouridineRNA, MessengerRNA, ProtozoanRNA, RibosomalpseudouridineToxoplasma gondii

Identifiers

PMID28851751
PMCPMC5689004
OpenAlexW2753241613

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.