Evidence map›Paper›PMID 28851693›Full record

ArticleCancer immunology research2017

The Antitumor Effects of Vaccine-Activated CD8

Sha Wu, Wei Zhu, Yibing Peng, Lan Wang, Yuan Hong, Lei Huang, Dayong Dong, Junping Xie, Todd Merchen, Edward Kruse and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer immunology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. CD8Cell reports. Medicine · 2026
    Review
  2. Article
  3. The diversity of CD8Nature reviews. Immunology · 2025
    Review
  4. Article
  5. Memory stem CD8Frontiers in cellular and infection microbiology · 2024
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Sha WuGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, Georgia.
Wei ZhuGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, Georgia.
Yibing PengGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, Georgia.
Lan WangGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, Georgia.
Yuan HongGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, Georgia.
Lei HuangGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, Georgia.
Dayong DongGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, Georgia.
Junping XieGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, Georgia.
Todd MerchenGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, Georgia.
Edward KruseGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, Georgia.
Zong Sheng GuoUniversity of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
David BartlettUniversity of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
Ning FuDivision of Laboratory Medicine of Zhujiang Hospital, Southern Medical University, Guangzhou, China. yhe@augusta.edu zfzn2013@126.com.
Yukai HeGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, Georgia. yhe@augusta.edu zfzn2013@126.com.
Augusta University · USUPMC Hillman Cancer Center · USZhujiang Hospital · CN

Funding

Engineering alpha fetoprotein and glypican-3 to develop hepatoma (HCC) vaccinesR01CA168912 · NCI · AUGUSTA UNIVERSITY · PI HE, YUKAI · 2014 to 2018
$1.6M
NCI NIH HHS R01 CA168912
6 · The paper itself

Abstract

To understand why vaccine-activated tumor-specific T cells often fail to generate antitumor effects, we studied two α-fetoprotein-specific CD8

Indexed as

Immunologic MemorySignal Transductionalpha-FetoproteinsAnimalsAntigens, NeoplasmApoptosisCancer VaccinesCD8-Positive T-LymphocytesDisease Models, AnimalEpitopes, T-LymphocyteH-2 AntigensHumansLymphocyte ActivationMiceNeoplasmsPeptidesalpha-FetoproteinsAntigens, NeoplasmCancer VaccinesEpitopes, T-LymphocyteH-2 AntigensPeptidesProto-Oncogene Proteins c-bcl-2Receptors, Antigen, T-Cell

Identifiers

PMID28851693
PMCPMC5626646
OpenAlexW2752540906

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.