ArticleCancer prevention research (Philadelphia, Pa.)2017
Tobacco-Specific Carcinogens Induce Hypermethylation, DNA Adducts, and DNA Damage in Bladder Cancer.
RetractedOpen access · greenAbstract readComparative StudyValidation StudyRetracted Publication
In one paragraph
Article in Cancer prevention research (Philadelphia, Pa.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 35 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: An update of a systematic literature review.Mutation research. Reviews in mutation researchPooled it
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- Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2023Review
- Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer.BMC cancer · 2023Article
- History of the Relationship Between Smoking and Bladder Cancer: A Public Health Perspective.Urology · 2023Article
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- Molecular mechanism of benzo [a] pyrene regulating lipid metabolism via aryl hydrocarbon receptor.Lipids in health and disease · 2022Article
- Role of Chromatin Modifying Complexes and Therapeutic Opportunities in Bladder Cancer.Bladder cancer (Amsterdam, Netherlands) · 2022Review
- Opium and Cigarette Smoking are Independently Associated with Bladder Cancer: The Findings of a Matched Case - Control Study.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Combined effects of cigarette smoking, DNA methyltransferase 3B genetic polymorphism, and DNA damage on lung cancer.BMC cancer · 2021Article
- Untargeted Urinary Metabolomics and Children's Exposure to Secondhand Smoke: The Influence of Individual Differences.International journal of environmental research and public health · 2021Article
- Can Smoking Cause Differences in Urine Microbiome in Male Patients With Bladder Cancer? A Retrospective Study.Frontiers in oncology · 2021Article
- Smoking status and pathological response to neoadjuvant chemotherapy among patients with bladder cancer: a pooled analysis.Translational andrology and urology · 2021Article
Corrections and comments
- Retraction · 2024-06-04Concerns/Issues about Image · Falsification/Fabrication of Image · Investigation by Company/Institution · Investigation by Journal/Publisher · Objections by Author(s) · Upgrade/Update of Prior Notice(s) · · See also: https://pubpeer.com/publications/BAC7774EB1B3E441314ECD8096BB97
- Expression of concern · 2019-09-03Concerns/Issues about Data · Investigation by Company/Institution · Manipulation of Images · Updated to Retraction · · See also: https://pubpeer.com/publications/BAC7774EB1B3E441314ECD8096BB97
- Expression of concern
- Retracted
Authors and funding
33 authors at 13 institutions in 2 countries.
Feng JinDan L. Duncan Cancer Center, Advanced Technology Core, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas.
Jose ThaiparambilDepartment of Radiology, Houston Methodist Research Institute, Houston, Texas.
Sri Ramya DonepudiDan L. Duncan Cancer Center, Advanced Technology Core, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas.
Venkatrao VantakuDepartment of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas.
Danthasinghe Waduge Badrajee PiyarathnaDepartment of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas.
Suman MaityDan L. Duncan Cancer Center, Advanced Technology Core, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas.
Rashmi KrishnapuramDepartment of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas.
Vasanta PutluriDan L. Duncan Cancer Center, Advanced Technology Core, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas.
Franklin GuVerna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas.
Preeti PurwahaDepartment of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas.
Salil Kumar BhowmikDepartment of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas.
Chandrashekar R AmbatiDan L. Duncan Cancer Center, Advanced Technology Core, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas.
Friedrich-Carl von RundstedtScott Department of Urology, Baylor College of Medicine, Houston, Texas.
Florian RoghmannDepartment of Urology, Marien Hospital, Ruhr-University Bochum, Herne, Germany.
Sebastian BergDepartment of Urology, Marien Hospital, Ruhr-University Bochum, Herne, Germany.
Joachim NoldusDepartment of Urology, Marien Hospital, Ruhr-University Bochum, Herne, Germany.
Kimal RajapaksheDepartment of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas.
Daniel GöddeDepartment of Pathology, Witten-Herdecke University, Wuppertal, Germany.
Stephan RothDepartment of Urology Helios Klinikum, Witten-Herdecke University, Wuppertal, Germany.
Stephan StörkelDepartment of Pathology, Witten-Herdecke University, Wuppertal, Germany.
Stephan DegenerDepartment of Urology Helios Klinikum, Witten-Herdecke University, Wuppertal, Germany.
George MichailidisDepartment of Statistics, University of Florida, Gainesville, Florida.
Benny Abraham KaipparettuDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.
Balasubramanyam KaranamDepartment of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, Alabama.
Martha K TerrisAugusta University, Augusta, Georgia.
Shyam M KavuriLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Seth P LernerVerna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas.
Farrah KheradmandDepartment of Medicine & Center for Translational Research in Inflammatory Diseases, Michael E. DeBakey VA, Baylor College of Medicine, Houston, Texas.
Cristian CoarfaDan L. Duncan Cancer Center, Advanced Technology Core, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas.
Arun SreekumarDan L. Duncan Cancer Center, Advanced Technology Core, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas.
Yair LotanDepartment of Urology, University of Texas Southwestern, Dallas, Texas.
Randa El-ZeinDepartment of Radiology, Houston Methodist Research Institute, Houston, Texas.
Nagireddy PutluriDan L. Duncan Cancer Center, Advanced Technology Core, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas. putluri@bcm.edu.
Baylor College of Medicine · USChildren's Cancer Center · USUniversitätsklinik Marien Hospital Herne · DEHelios Universitätsklinikum Wuppertal · DEHouston Methodist · USWitten/Herdecke University · DEAugusta University Health · USBaylor Genetics · USFriedrich Schiller University Jena · DEMichael E. DeBakey VA Medical Center · USThe University of Texas Southwestern Medical Center · USTuskegee University · USUniversity of Florida · US
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9MTissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3MTissue/InformaticsP50CA186786 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ganesh S Palapattu · 2014 to 2026
$27.6MTRANSGENIC MOUSE MODELS TO STUDY OVARIAN FUNCTIONU54HD007495 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MATZUK, MARTIN M. · 1998 to 2013
$19.9MEpitomic Biomarkers of Prostate CancerU01CA111275 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHINNAIYAN, ARUL M, RUBIN, MARK A. · 2004 to 2015
$6.8MGenetic & Metabolic Dissection of the CaMKKbeta Signaling Axis in Prostate CancerR01CA184208 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI FRIGO, DANIEL EDWARD · 2015 to 2019
$1.9MMETABOLOMIC PROFILING AND BIOLOGIC BASIS OF RACIAL DISPARITY IN PROSTATE CANCERU01CA167234 · NCI · BAYLOR COLLEGE OF MEDICINE · PI PALAPATTU, GANESH S, SREEKUMAR, ARUN · 2012 to 2016
$1.9MRacial Disparity in Bladder Cancer and Identification of Altered Metabolism in African American Compare to European Bladder CancerR01CA220297 · NCI · BAYLOR COLLEGE OF MEDICINE · PI PUTLURI, NAGIREDDY · 2017 to 2021
$1.8MGROWTH AND DIFFERENTIATION IN EUKARYOTEST32HD007495 · NICHD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI KINTNER, CHRISTOPHER ROBERT · 1995 to 2009
$1.6MIntegrative Metabolomics of Prostate Cancer ProgressionR01CA133458 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SREEKUMAR, ARUN · 2008 to 2012
$1.6MIntegromics with Application to Prostate Cancer ProgressionRC1CA145444 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MICHAILIDIS, GEORGE · 2009 to 2010
$999kMitochondria-nuclear crosstalk in triple negative breast cancer racial disparityR21CA179720 · NCI · BAYLOR COLLEGE OF MEDICINE · PI KAIPPARETTU, BENNY ABRAHAM · 2013 to 2015
$623kNCI NIH HHS F30 CA196108NCI NIH HHS P30 CA125123NCI NIH HHS P50 CA186786NCI NIH HHS R01 CA133458NCI NIH HHS R01 CA184208NCI NIH HHS R01 CA220297NCI NIH HHS R21 CA173150NCI NIH HHS R21 CA179720NCI NIH HHS R21 CA205257NCI NIH HHS RC1 CA145444NCI NIH HHS U01 CA111275NCI NIH HHS U01 CA167234NICHD NIH HHS P30 HD007495NICHD NIH HHS T32 HD007495NICHD NIH HHS U54 HD007495NIDDK NIH HHS P30 DK056338
Abstract
Smoking is a major risk factor for the development of bladder cancer; however, the functional consequences of the carcinogens in tobacco smoke and bladder cancer-associated metabolic alterations remain poorly defined. We assessed the metabolic profiles in bladder cancer smokers and non-smokers and identified the key alterations in their metabolism. LC/MS and bioinformatic analysis were performed to determine the metabolome associated with bladder cancer smokers and were further validated in cell line models. Smokers with bladder cancer were found to have elevated levels of methylated metabolites, polycyclic aromatic hydrocarbons, DNA adducts, and DNA damage. DNA methyltransferase 1 (DNMT1) expression was significantly higher in smokers than non-smokers with bladder cancer. An integromics approach, using multiple patient cohorts, revealed strong associations between smokers and high-grade bladder cancer.
Indexed as
AzacitidineBenzo(a)pyreneBiomarkers, TumorButanonesCarcinogensCell Line, TumorCohort StudiesDecitabineDNA AdductsDNA (Cytosine-5-)-Methyltransferase 1DNA DamageDNA MethylationEarly Detection of CancerFemaleHumansMale4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneAzacitidineBenzo(a)pyreneBiomarkers, TumorButanonesCarcinogensDecitabineDNA AdductsDNA (Cytosine-5-)-Methyltransferase 1DNMT1 protein, humanmethylethyl ketoneMutagensNitrosaminesPolycyclic Aromatic Hydrocarbons
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.