Evidence map›Paper›PMID 28851689›Full record

ArticleCancer prevention research (Philadelphia, Pa.)2017

The Second-Generation PGI2 Analogue Treprostinil Fails to Chemoprevent Tumors in a Murine Lung Adenocarcinoma Model.

Lori Dwyer-Nield, Gregory A Hickey, Micah Friedman, Kevin Choo, Debbie G McArthur, Meredith A Tennis, Melissa L New, Mark Geraci, Robert L Keith

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer prevention research (Philadelphia, Pa.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. TARGETING THE PROSTACYCLIN/PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA AXIS IN LUNG CANCER CHEMOPREVENTION.Transactions of the American Clinical and Climatological Association · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Lori Dwyer-NieldSkaggs School of Pharmacy and Pharmaceutical Science, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Gregory A HickeyDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Micah FriedmanEastern Colorado Veterans Affairs Medical Center, Denver, Colorado.
Kevin ChooEastern Colorado Veterans Affairs Medical Center, Denver, Colorado.
Debbie G McArthurEastern Colorado Veterans Affairs Medical Center, Denver, Colorado.
Meredith A TennisDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Melissa L NewDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Mark GeraciDepartment of Medicine, Indiana University, Indianapolis, Indiana.
Robert L KeithDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado. Robert.keith@ucdenver.edu.
Denver VA Medical Center · USUniversity of Colorado Anschutz Medical Campus · USIndiana University – Purdue University Indianapolis · US

Funding

Tissue Bank and Biomarkers CoreP50CA058187 · NCI · UNIVERSITY OF COLORADO DENVER · PI BUNN, PAUL A. · 1992 to 2018
$43.8M
PPAR gamma Agonists for Lung Cancer ChemopreventionI01BX000382 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI KEITH, ROBERT · 2011 to 2020
–
BLRD VA I01 BX000382NCI NIH HHS P50 CA058187
6 · The paper itself

Abstract

Prostacyclin (prostaglandin I

Indexed as

AdenocarcinomaAdenocarcinoma of LungAnimalsAntihypertensive AgentsBiological AvailabilityCarcinogensCell Line, TumorCell ProliferationDrug Evaluation, PreclinicalEpoprostenolFemaleHumansLungLung NeoplasmsMiceMice, TransgenicAntihypertensive AgentsCarcinogensCXCR4 protein, mouseEpoprostenolReceptors, CXCR4Receptors, ProstaglandintreprostinilUrethane

Identifiers

PMID28851689
PMCPMC5769875
OpenAlexW2752881180

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.