Evidence map›Paper›PMID 28851604›Full record

ReviewTrends in genetics : TIG2017

Regulatory Logic Underlying Diversification of the Neural Crest.

Megan L Martik, Marianne E Bronner

Abstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. A dual role for GLI3 signaling in neural crest development.Development (Cambridge, England) · 2026
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Ectomesenchymal identity emerges via relief ofbioRxiv : the preprint server for biology · 2025
    Article
  18. Article
  19. Reactivation of an embryonic cardiac neural crest transcriptional profile during zebrafish heart regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Article

70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Megan L MartikDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Marianne E BronnerDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: mbronner@caltech.edu.

Funding

Transcriptional Casualty in Embryonic Morphogenesis: from the Specifications GRNP01HD037105 · NICHD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI DAVIDSON, ERIC H · 1999 to 2018
$27.1M
Gene Regulatory Network Controlling Premigratory Cranial vs Trunk Neural CrestR01DE024157 · NIDCR · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BRONNER, MARIANNE · 2014 to 2025
$4.0M
Evolutionary Origin of Vertebrate Neural Crest Gene NetworksR01DE017911 · NIDCR · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BRONNER, MARIANNE · 2007 to 2011
$2.7M
Regulatory Changes Mediating Emergence of Novel Neural Crest TraitsR01NS086907 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BRONNER, MARIANNE · 2014 to 2018
$1.8M
NICHD NIH HHS P01 HD037105NIDCR NIH HHS R01 DE017911NIDCR NIH HHS R01 DE024157NINDS NIH HHS R01 NS086907
6 · The paper itself

Abstract

The neural crest is a transient, multipotent population of cells that arises at the border of the developing nervous system. After closure of the neural tube, these cells undergo an epithelial-to-mesenchymal transition (EMT) to delaminate and migrate, often to distant locations in the embryo. Neural crest cells give rise to a diverse array of derivatives including neurons and glia of the peripheral nervous system, melanocytes, and bone and cartilage of the face. A gene regulatory network (GRN) controls the specification, delamination, migration, and differentiation of this fascinating cell type. With increasing technological advances, direct linkages within the neural crest GRN are being uncovered. The underlying circuitry is useful for understanding important topics such as reprogramming, evolution, and disease.

Indexed as

AnimalsGene Regulatory NetworksHumansNeural Crest

Identifiers

PMID28851604
PMCPMC5610108

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.