Trial reportAlzheimer's research & therapy2017
Structured physical exercise improves neuropsychiatric symptoms in acute dementia care: a hospital-based RCT.
Trial report in Alzheimer's research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Use of Wearable Technology for Measuring and Characterizing Sedentary Behavior in People With Mild Cognitive Impairment and Dementia: Systematic Review.JMIR aging · 2026Pooled it
- Characteristics, outcomes, facilitators and barriers for psychosocial interventions on inpatient mental health dementia wards: a systematic review.BMC geriatrics · 2024Pooled it
- Effects of exercise interventions in Alzheimer's disease: A meta-analysis.Brain and behavior · 2023Pooled it
- Exercise for acutely hospitalised older medical patients.The Cochrane database of systematic reviews · 2022Pooled it
- Acceptability of a Dyadic Tai Chi Intervention for Older People Living With Dementia and Their Informal Carers.Journal of aging and physical activity · 2019Trial
- Feasibility of a short-term intensive home-based cognitive and physical training program for older adults: a single-arm pilot study.BMC geriatrics · 2026Article
- Exercise Interventions for Cognitive and Functional Outcomes in Dementia: A Systematic Review and Meta-Analysis Exploring Dose Metrics, Heterogeneity, and Implementation-Relevant Factors.Healthcare (Basel, Switzerland) · 2026Review
- Feasibility of the tailored activity program to bridge hospital and community care for people living with dementia and behavioral disorders: The "Continu-A-Mente" project.BMC geriatrics · 2026Article
- Advancing Care in Alzheimer's Disease: Current Treatments and Their Impact on Quality of Life.Cureus · 2025Review
- Article
- The association of physical activity and behavioral and psychological symptoms among a sample of hospitalized older adults living with dementia.International journal of geriatric psychiatry · 2023Article
- Optimizing the Physical & Social Environment Within Hospitals for Patients with Dementia: a Systematic Review.Canadian geriatrics journal : CGJ · 2022Review
- Care for dementia patients and caregivers amid COVID-19 pandemic.Cerebral circulation - cognition and behavior · 2022Review
- The Impact of Exercising in the Quality of Life of People with Dementia-Alzheimer's Disease.Advances in experimental medicine and biology · 2021Review
- [Exercise and physical training as interventions in gerontopsychiatry].Zeitschrift fur Gerontologie und Geriatrie · 2020Review
- Statistical learning of mobility patterns from long-term monitoring of locomotor behaviour with body-worn sensors.Scientific reports · 2018Article
- The Multidisciplinary Approach to Alzheimer's Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment.Frontiers in neurology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe primary objective of this trial is to investigate the effects of a short-term exercise program on neuropsychiatric signs and symptoms in acute hospital dementia care.
methodsWithin a hospital-based randomized controlled trial, the intervention group conducted a 2-week exercise program with four 20-min exercise sessions on 3 days per week. The control group conducted a social stimulation program. Effects on neuropsychiatric signs and symptoms were measured via the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change, the Neuropsychiatric Inventory, and the Cohen-Mansfield Agitation Inventory. The antipsychotic and sedative dosage was quantified by olanzapine and diazepam equivalents.
resultsEighty-five patients were randomized via minimization to an intervention group (IG) and a control group (CG). Seventy patients (82%) (mean age 80 years, 33 females, mean Mini Mental State Examination score 18.3 points) completed the trial. As compared to the CG (n = 35), the IG (n = 35) showed significantly reduced neuropsychiatric signs and symptoms. Especially, agitated behavior and lability improved. There were no between-group differences concerning antipsychotic and benzodiazepine medication.
conclusionsThis exercise program is easily applicable in hospital dementia care and significantly reduces neuropsychiatric signs and symptoms in patients suffering from predominantly moderate stages of dementia.
trial registrationGerman Clinical Trial Register DRKS00006740 . Registered 28 October 2014.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.