ArticleEnvironmental health : a global access science source2017
Pesticide exposure assessed through agricultural crop proximity and risk of amyotrophic lateral sclerosis.
Article in Environmental health : a global access science source, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
31 citing papers in PubMed, 5 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Urbanization, air pollution, and water pollution: Identification of potential environmental risk factors associated with amyotrophic lateral sclerosis using systematic reviews.Frontiers in neurology · 2023Pooled it
- Is Greenness Associated with Dementia? A Systematic Review and Dose-Response Meta-analysis.Current environmental health reports · 2022Pooled it
- Residential exposure to electromagnetic fields and risk of amyotrophic lateral sclerosis: a dose-response meta-analysis.Scientific reports · 2021Pooled it
- Association between Urban Greenspace and Health: A Systematic Review of Literature.International journal of environmental research and public health · 2021Pooled it
- The Role of MicroRNAs in Patients with Amyotrophic Lateral Sclerosis.Journal of molecular neuroscience : MN · 2018Pooled it
- Green space exposure and risk of amyotrophic lateral sclerosis: a population-based case-control study in Northern Italy.Environmental health : a global access science source · 2026Article
- Croplands proximity is associated with amyotrophic lateral sclerosis incidence and age at onset.European journal of neurology · 2025Article
- Residential exposure associations with ALS risk, survival, and phenotype: a Michigan-based case-control study.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2024Article
- Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort.Journal of neurology, neurosurgery, and psychiatry · 2024Article
- Article
- Mycotoxins and Amyotrophic Lateral Sclerosis: Food Exposure, Nutritional Implications and Dietary Solutions.CNS & neurological disorders drug targets · 2024Review
- The amyotrophic lateral sclerosis exposome: recent advances and future directions.Nature reviews. Neurology · 2023Review
- Interplay of Metallome and Metabolome in Amyotrophic Lateral Sclerosis: A Study on Cerebrospinal Fluid of Patients Carrying Disease-Related Gene Mutations.ACS chemical neuroscience · 2023Article
- Review
- Residential proximity to petrol stations and risk of childhood leukemia.European journal of epidemiology · 2023Article
- Oxidative Stress in Amyotrophic Lateral Sclerosis: Synergy of Genetic and Environmental Factors.International journal of molecular sciences · 2022Review
- Epidemiological, Clinical and Genetic Features of ALS in the Last Decade: A Prospective Population-Based Study in the Emilia Romagna Region of Italy.Biomedicines · 2022Article
- mFrontiers in neurology · 2022Review
- Pesticides applied to crops and amyotrophic lateral sclerosis risk in the U.S.Neurotoxicology · 2021Article
- Is Chronic Exposure to Raw Water a Possible Risk Factor for Amyotrophic Lateral Sclerosis? A Pilot Case-Control Study.Brain sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidemiologic studies have raised the possibility that some pesticide compounds induce the neurodegenerative disease amyotrophic lateral sclerosis (ALS), though the available evidence is not entirely consistent.
methodsWe conducted a population-based case-control study in two Italian populations to assess the extent to which residence in the vicinity of agricultural crops associated with the application of neurotoxic pesticides is a risk factor for ALS, using crop acreage in proximity to the residence as an index of exposure.
resultsBased on 703 cases and 2737 controls, we computed an ALS odds ratio of 0.92 (95% confidence interval 0.78-1.09) for those in proximity to agricultural land. Results were not substantially different when using alternative exposure categories or when analyzing specific crop types, with the exception of a higher risk related to exposure to citrus orchards and olive groves in Southern Italy, though based on few exposed subjects (N = 89 and 8, respectively). There was little evidence of any dose-response relation between crop proximity and ALS risk, and using long-term residence instead of current residence did not substantially change our estimates.
conclusionsThough our index of exposure is indirect and subject to considerable misclassification, our results offer little support for the hypothesis that neurotoxic pesticide exposure increases ALS risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.