Evidence map›Paper›PMID 28851420›Full record

Trial reportTrials2017

Randomized study exploring the combination of radiotherapy with two types of acupuncture treatment (ROSETTA): study protocol for a randomized controlled trial.

Rebecca Asadpour, Kerstin A Kessel, Tom Bruckner, Serkan Sertel, Stephanie E Combs

Registry-linked trialOpen access · goldAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02674646 (RandOmized Study Exploring the Combination of radioTherapy With Two Types of Acupuncture Treatment), which is not on this map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02674646 phase2unknown statusnot on this map

RandOmized Study Exploring the Combination of radioTherapy With Two Types of Acupuncture Treatment: The ROSETTA Trial

TypeinterventionalSponsorTechnical University of MunichRan2016 to 2018Enrolled74ConditionsCancerArmsRadiotherapy, Needle Acupuncture
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Acupuncture for radiation-induced toxicity in head and neck squamous cell carcinoma: a systematic review based on PICO criteria.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Pooled it
  2. Pooled it
  3. Article
  4. Complementary medicine in radiation oncology : German health care professionals' current qualifications and therapeutic methods.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Rebecca AsadpourDepartment of Radiation Oncology, Technische Universität München (TUM), Klinikum rechts der Isar, Ismaninger Straße 22, 81675, Munich, Germany.
Kerstin A KesselDepartment of Radiation Oncology, Technische Universität München (TUM), Klinikum rechts der Isar, Ismaninger Straße 22, 81675, Munich, Germany.
Tom BrucknerDepartment of Medical Biometry, Institute of Medical Biometry and Informatics (IMBI), Universität Heidelberg, Im Neuenheimer Feld 305, 69120, Heidelberg, Germany.
Serkan SertelPraxisgemeinschaft Prof. Sertel & Dr. Passerino , Rottstrasse 39, 67061, Ludwigshafen am Rhein, Germany.
Stephanie E CombsDepartment of Radiation Oncology, Technische Universität München (TUM), Klinikum rechts der Isar, Ismaninger Straße 22, 81675, Munich, Germany. stephanie.combs@tum.de.
Heidelberg University · DEInstitute of Bioinformatics and Systems Biology · DEKlinikum rechts der Isar · DETechnical University of Munich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdverse effects such as fatigue, pain, erythema, nausea and vomiting are commonly known in patients undergoing irradiation (RT) alone or in combination with chemotherapy (RCHT). Patients suffering from these symptoms are limited in their daily life and their quality of life (QOL) is often reduced. As addressed in several trials, acupuncture can cause amelioration of these specific disorders. Especially for pain symptoms, several groups have shown efficacy of acupuncture. To what extent the difference between traditional acupuncture (verum acupuncture) and false acupuncture (sham acupuncture) is in reducing side effects and improvement of QOL is not clear. METHODS/

designROSETTA is a prospective randomized phase II trial (version 1.0) to examine the efficacy of traditional acupuncture in patients with RT-related side effects. In the experimental (verum) arm (n = 37) an experienced acupuncture-trained person will treat dedicated acupuncture points. In the control (sham) arm (n = 37) sham acupuncture will be performed to provide a blinded comparison of results. DISCUSSION: This is the first randomized prospective trial to evaluate the effect of traditional acupuncture on RT-related side effects such as fatigue and QOL.

trial registrationClinicalTrials.gov, NCT02674646 . Registered on 8 December 2015.

Indexed as

Acupuncture PointsAcupuncture TherapyFatigueGermanyHumansNeoplasmsProspective StudiesQuality of LifeRadiotherapySurveys and QuestionnairesTime FactorsTreatment OutcomeAcupunctureFatigueQuality of life (QOL)RadiotherapySham-controlled trial

Identifiers

PMID28851420
PMCPMC5575840
OpenAlexW2752484328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.