Evidence map›Paper›PMID 28851128›Full record

ReviewJournal of biophotonics2018

Current status, pitfalls and future directions in the diagnosis and therapy of lymphatic malformation.

Ravi W Sun, Valery V Tuchin, Vladimir P Zharov, Ekaterina I Galanzha, Gresham T Richter

Open access · greenAbstract readReview
In one paragraph

Review in Journal of biophotonics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Risk factors for sequelae after surgery for lymphatic malformations in children.Journal of vascular surgery. Venous and lymphatic disorders · 2024
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. An Unusual Presentation of a Lymphatic Malformation in an Adult: A Case Report.Clinical practice and cases in emergency medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Ravi W SunDepartment of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas.ORCID http://orcid.org/0000-0002-0494-7547
Valery V TuchinResearch-Educational Institute of Optics and Biophotonics, Saratov National Research State University, Saratov, Russia.ORCID http://orcid.org/0000-0001-7479-2694
Vladimir P ZharovDepartment of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas.ORCID http://orcid.org/0000-0003-4773-0548
Ekaterina I GalanzhaDepartment of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas.ORCID http://orcid.org/0000-0002-1734-3179
Gresham T RichterDepartment of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Arkansas Children's Hospital · USUniversity of Arkansas for Medical Sciences · USSaratov State University · RU

Funding

In vivo real-time detection of circulating melanoma cellsR01CA131164 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI SUEN, JAMES · 2009 to 2019
$3.1M
Photoswitchable nanoprobes for in vivo flow cytometryR01EB017217 · NIBIB · UNIV OF ARKANSAS FOR MED SCIS · PI ZHAROV, VLADIMIR P · 2014 to 2017
$1.3M
Interaction of gold nanoparticles with lymphatic vesselsR21EB022698 · NIBIB · UNIV OF ARKANSAS FOR MED SCIS · PI GALANZHA, EKATERINA I. · 2016 to 2017
$398k
NCI NIH HHS R01 CA131164NIBIB NIH HHS R01 EB017217NIBIB NIH HHS R21 EB022698
6 · The paper itself

Abstract

Lymphatic malformations are complex congenital vascular lesions composed of dilated, abnormal lymphatic channels of varying size that can result in significant esthetic and physical impairment due to relentless growth. Lymphatic malformations comprised of micro-lymphatic channels (microcystic) integrate and infiltrate normal soft tissue, leading to a locally invasive mass. Ultrasonography and magnetic resonance imaging assist in the diagnosis but are unable to detect microvasculature present in microcystic lymphatic malformations. In this review, we examine existing tools and elaborate on alternative diagnostic methods in assessing lymphatic malformations. In particular, photoacoustics, low-toxicity nanoparticles and optical clearing can overcome existing challenges in the examination of lymphatic channels in vivo. In combination with photothermal scanning and flow cytometry, Photoacoustic techniques may provide a versatile tool for lymphatic-related clinical applications, potentially leading to a single diagnostic and therapeutic platform to overcome limitations in current imaging techniques and permit targeted theranostics of microcystic lymphatic malformations.

Indexed as

Diagnostic ImagingHumansLymphatic AbnormalitiesNanomedicineOptical Phenomenalymphangiomalymphatic malformationmacrocysticmicrocysticnanoparticlesoptical clearingphotoacousticsphotothermal blood and lymph vessel therapy

Identifiers

PMID28851128
PMCPMC11184539
OpenAlexW2753748486

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.