ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2018
Optimizing a micro-computed tomography-based surrogate measurement of bone-implant contact.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Comparative Evaluation of Bone-Implant Contact in Various Surface-Treated Dental Implants Using High-Resolution Micro-CT in Rabbits' Bone.Materials (Basel, Switzerland) · 2024Article
- Comparative analysis of theJournal of periodontal & implant science · 2024Article
- The relative contribution of bone microarchitecture and matrix composition to implant fixation strength in rats.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Comparison of three-dimensional digital analyses and two-dimensional histomorphometric analyses of the bone-implant interface.PloS one · 2022Article
- Correlation between two-dimensional micro-CT and histomorphometry for assessment of the implant osseointegration in rabbit tibia model.Biomaterials research · 2021Article
- Biomechanics of Implant Fixation in Osteoporotic Bone.Current osteoporosis reports · 2020Review
- Early changes in serum osteocalcin and body weight are predictive of implant fixation in a rat model of implant loosening.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Implant surface alters compartmental-specific contributions to fixation strength in rats.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- An In Vivo Study in Rat Femurs of Bioactive Silicate Coatings on Titanium Dental Implants.Journal of clinical medicine · 2020Article
- Acquisition of Quasi-Monochromatic Dual-Energy in a Microfocus X-ray Generator and Development of Applied Technology.Diagnostics (Basel, Switzerland) · 2019Article
- A multiscale analytical approach to evaluate osseointegration.Journal of materials science. Materials in medicine · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Histology and backscatter scanning electron microscopy (bSEM) are the current gold standard methods for quantifying bone-implant contact (BIC), but are inherently destructive. Microcomputed tomography (μCT) is a non-destructive alternative, but attempts to validate μCT-based assessment of BIC in animal models have produced conflicting results. We previously showed in a rat model using a 1.5 mm diameter titanium implant that the extent of the metal-induced artefact precluded accurate measurement of bone sufficiently close to the interface to assess BIC. Recently introduced commercial laboratory μCT scanners have smaller voxels and improved imaging capabilities, possibly overcoming this limitation. The goals of the present study were to establish an approach for optimizing μCT imaging parameters and to validate μCT-based assessment of BIC. In an empirical parametric study using a 1.5 mm diameter titanium implant, we determined 90 kVp, 88 µA, 1.5 μm isotropic voxel size, 1600 projections/180°, and 750 ms integration time to be optimal. Using specimens from an in vivo rat experiment, we found significant correlations between bSEM and μCT for BIC with the manufacturer's automated analysis routine (r = 0.716, p = 0.003) or a line-intercept method (r = 0.797, p = 0.010). Thus, this newer generation scanner's improved imaging capability reduced the extent of the metal-induced artefact zone enough to permit assessment of BIC. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:979-986, 2018.
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