Observational studyJournal of critical care2018
Thiamine in septic shock patients with alcohol use disorders: An observational pilot study.
Observational study in Journal of critical care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores.Scientific reports · 2022Trial
- A Randomized Pilot Trial to Evaluate the Bioavailability of Natural versus Synthetic Vitamin B Complexes in Healthy Humans and Their Effects on Homocysteine, Oxidative Stress, and Antioxidant Levels.Oxidative medicine and cellular longevity · 2019Trial
- What do we know about micronutrients in critically ill patients? A narrative review.JPEN. Journal of parenteral and enteral nutrition · 2025Review
- Cross-Sectional Study of Thiamine Deficiency and Its Associated Risks in Emergency Care.The western journal of emergency medicine · 2024Article
- Thiamine Supplementation in Patients With Alcohol Use Disorder Presenting With Acute Critical Illness : A Nationwide Retrospective Observational Study.Annals of internal medicine · 2022Observational
- Vitamin therapy in sepsis.Pediatric research · 2022Review
- Effects of triple combination of hydrocortisone, thiamine, and Vitamin C on clinical outcome in patients with septic shock: A single-center randomized controlled trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Proinflammatory cytokines inhibit thiamin uptake by human and mouse pancreatic acinar cells: involvement of transcriptional mechanism(s).American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Insights Into Thiamine Supplementation in Patients With Septic Shock.Frontiers in medicine · 2021Review
- [Lactate in emergency medicine].Der Anaesthesist · 2020Review
- Thiamine (vitamin B1) in septic shock: a targeted therapy.Journal of thoracic disease · 2020Review
- Effect of bacterial flagellin on thiamin uptake by human and mouse pancreatic acinar cells: inhibition mediated at the level of transcription of thiamin transporters 1 and 2.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Effectiveness of thiamine therapy in mortality rate in patients with septic shock: A systematic review and meta-analysis.International journal of critical illness and injury scienceArticle
- Evaluating the role of high-dose intravenous thiamine supplementation for lactate clearance in patients with cirrhosis and sepsis.International journal of critical illness and injury scienceArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
purposeAlcohol-use disorders (AUDs) have been associated with increased sepsis-related mortality. As patients with AUDs are often thiamine deficient, we investigated practice patterns relating to thiamine administration in patients with AUDs presenting with septic shock and explored the association between receipt of thiamine and mortality. MATERIALS: We performed a retrospective cohort study of patients presenting with septic shock between 2008 and 2014 at a single tertiary care center. We identified patients with an AUD diagnosis, orders for microbial cultures and use of antibiotics, vasopressor dependency, and lactate levels≥4mmol/L. We excluded those who received thiamine later than 48h of sepsis onset.
resultsWe included 53 patients. Thirty-four (64%) patients received thiamine. Five patients (15%) received their first thiamine dose in the emergency department. The median time to thiamine administration was 9 (quartiles: 4, 18) hours. The first thiamine dose was most often given parenterally (68%) and for 100mg (88%). In those receiving thiamine, 15/34 (44%) died, compared to 15/19 (79%) of those not receiving thiamine, p=0.02.
conclusionsA considerable proportion of patients with AUDs admitted for septic shock do not receive thiamine. Thiamine administration in this patient population was associated with decreased mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.