Evidence map›Paper›PMID 28850788›Full record

ArticleBiomacromolecules2017

Tuning and Predicting Mesh Size and Protein Release from Step Growth Hydrogels.

Matthew S Rehmann, Kelsi M Skeens, Prathamesh M Kharkar, Eden M Ford, Emanual Maverakis, Kelvin H Lee, April M Kloxin

Abstract read
In one paragraph

Article in Biomacromolecules, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Ultrasound-responsive composite hydrogels: Design rules for spatiotemporally controlled drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthew S RehmannDepartment of Chemical and Biomolecular Engineering, University of Delaware , 150 Academy Street, Newark, Delaware 19716, United States.
Kelsi M SkeensDepartment of Chemical and Biomolecular Engineering, University of Delaware , 150 Academy Street, Newark, Delaware 19716, United States.
Prathamesh M KharkarDepartment of Materials Science and Engineering, University of Delaware , 201 DuPont Hall, Newark, Delaware 19716, United States.
Eden M FordDepartment of Chemical and Biomolecular Engineering, University of Delaware , 150 Academy Street, Newark, Delaware 19716, United States.
Emanual MaverakisDepartment of Dermatology, School of Medicine, University of California , Davis, California 95616, United States.
Kelvin H LeeDepartment of Chemical and Biomolecular Engineering, University of Delaware , 150 Academy Street, Newark, Delaware 19716, United States.ORCID http://orcid.org/0000-0003-0908-2981
April M KloxinDepartment of Chemical and Biomolecular Engineering, University of Delaware , 150 Academy Street, Newark, Delaware 19716, United States.ORCID http://orcid.org/0000-0002-4594-2953

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura Marcu · 2002 to 2026
$84.9M
This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2014 to 2024
$26.8M
Pilot Research Subproject ProgramP30GM110758 · NIGMS · UNIVERSITY OF DELAWARE · PI BEEBE, THOMAS PAUL · 2014 to 2018
$5.8M
CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAININGT32GM008550 · NIGMS · UNIVERSITY OF DELAWARE · PI BAHNSON, BRIAN J · 1994 to 2018
$5.0M
NCI NIH HHS P30 CA093373NIGMS NIH HHS P20 GM104316NIGMS NIH HHS P30 GM110758NIGMS NIH HHS T32 GM008550
6 · The paper itself

Abstract

Hydrogel-based depots are of growing interest for release of biopharmaceuticals; however, a priori selection of hydrogel compositions that will retain proteins of interest and provide desired release profiles remains elusive. Toward addressing this, in this work, we have established a new tool for the facile assessment of protein release from hydrogels and applied it to evaluate the effectiveness of mesh size estimations on predicting protein retention or release. Poly(ethylene glycol) (PEG)-based hydrogel depots were formed by photoinitiated step growth polymerization of four-arm PEG functionalized with norbornene (PEG-norbornene, 4% w/w to 20% w/w, M

Indexed as

Drug LiberationBecaplerminCross-Linking ReagentsHydrogelsNorbornanesPolyethylene GlycolsPorosityProto-Oncogene Proteins c-sis2-norborneneBecaplerminCross-Linking ReagentsHydrogelsNorbornanesPolyethylene GlycolsProto-Oncogene Proteins c-sis

Identifiers

PMID28850788
PMCPMC6699171

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.