ArticlePloS one2017
Sex-based differences in myocardial gene expression in recently deceased organ donors with no prior cardiovascular disease.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 57 citations in OpenAlex.
- A sex-specific perspective on coronary microvascular dysfunction in HFpEF: from vascular to myocardial disease.Heart failure reviews · 2026Review
- Sex-stratified genetic regulators of cytokine production in the Dutch and Tanzanian populations.HGG advances · 2026Article
- Sex-Specific Disparities in the Female Vs Male Patient Population in Left Ventricular Assist Device Use.CJC open · 2025Review
- Sex-biased human thymic architecture guides T cell development through spatially defined niches.Developmental cell · 2025Article
- Sex and Age Differences in the Impact of Metabolic Syndrome on Heart Failure Development.Metabolites · 2024Review
- Hearts apart: sex differences in cardiac remodeling in health and disease.The Journal of clinical investigation · 2024Review
- Expression profiling of cochlear genes uncovers sex-based cellular function in mouse cochleae.Hearing research · 2024Article
- New role for cardiomyocytebioRxiv : the preprint server for biology · 2024Article
- Exploring the diagnostic and prognostic value of the C-reactive protein/lymphocyte ratio for dilated cardiomyopathy based on a real-world study.Scientific reports · 2023Article
- Seeking clarity on sex differences in cardiovascular complications of Down syndrome.American journal of physiology. Heart and circulatory physiology · 2023Article
- Sex chromosome mechanisms in cardiac development and disease.Nature cardiovascular research · 2023Article
- Developmental programming: adverse sexually dimorphic transcriptional programming of gestational testosterone excess in cardiac left ventricle of fetal sheep.Scientific reports · 2023Article
- Article
- Abnormal Cellular Phenotypes Induced by ThreeCells · 2023Article
- A role for misaligned gene expression of fetal gene program in the loss of female-specific cardiovascular protection in young obese and diabetic females.Frontiers in endocrinology · 2023Review
- Modeling sex differences in humans using isogenic induced pluripotent stem cells.Stem cell reports · 2022Article
- Sex-Related Differences in Genetic Cardiomyopathies.Journal of the American Heart Association · 2022Review
- Sex differences in acute cardiovascular care: a review and needs assessment.Cardiovascular research · 2022Review
- Sex-dependent transcription of cardiac electrophysiology and links to acetylation modifiers based on the GTEx database.Frontiers in cardiovascular medicine · 2022Article
- Sex differences in genetic architecture in the UK Biobank.Nature genetics · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sex differences in the development of the normal heart and the prevalence of cardiomyopathies have been reported. The molecular basis of these differences remains unclear. Sex differences in the human heart might be related to patterns of gene expression. Recent studies have shown that sex specific differences in gene expression in tissues including the brain, kidney, skeletal muscle, and liver. Similar data is limited for the heart. Herein we address this issue by analyzing donor and post-mortem adult human heart samples originating from 46 control individuals to study whole-genome gene expression in the human left ventricle. Using data from the genotype tissue expression (GTEx) project, we compared the transcriptome expression profiles of male and female hearts. We found that genes located on sex chromosomes were the most abundant ones among the sexually dimorphic genes. The majority of differentially expressed autosomal genes were those involved in the regulation of inflammation, which has been found to be an important contributor to left ventricular remodeling. Specifically, genes on autosomal chromosomes encoding chemokines with inflammatory functions (e.g. CCL4, CX3CL1, TNFAIP3) and a gene that regulates adhesion of immune cells to the endothelium (e.g., VCAM1) were identified with sex-specific expression levels. This study underlines the relevance of sex as an important modifier of cardiac gene expression. These results have important implications in the understanding of the differences in the physiology of the male and female heart transcriptome and how they may lead to different sex specific difference in human cardiac health and its control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.