Evidence map›Paper›PMID 28850328›Full record

ArticleeLife2017

Circular oligomerization is an intrinsic property of synaptotagmin.

Jing Wang, Feng Li, Oscar D Bello, Charles Vaughn Sindelar, Frédéric Pincet, Shyam S Krishnakumar, James E Rothman

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Calcium Sensors of Neurotransmitter Release.Advances in neurobiology · 2023
    Article
  5. Review
  6. Synaptotagmin rings as high-sensitivity regulators of synaptic vesicle docking and fusion.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  7. Article
  8. Synaptotagmin 1 oligomerization via the juxtamembrane linker regulates spontaneous and evoked neurotransmitter release.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  9. Article
  10. Article
  11. CaeLife · 2020
    Article
  12. Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  13. Article
  14. Article
  15. Structural basis for the clamping and CaNature communications · 2019
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Jing WangDepartments of Cell Biology, Yale University School of Medicine, New Haven, United States.
Feng LiDepartments of Cell Biology, Yale University School of Medicine, New Haven, United States.
Oscar D BelloDepartments of Cell Biology, Yale University School of Medicine, New Haven, United States.
Charles Vaughn SindelarDepartments of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, United States.ORCID 0000-0002-6646-7776
Frédéric PincetDepartments of Cell Biology, Yale University School of Medicine, New Haven, United States.
Shyam S KrishnakumarDepartments of Cell Biology, Yale University School of Medicine, New Haven, United States.ORCID 0000-0001-6148-3251
James E RothmanDepartments of Cell Biology, Yale University School of Medicine, New Haven, United States.ORCID 0000-0001-8653-8650
Yale University · USCentre National de la Recherche Scientifique · FR

Funding

Regulation of Membrane Fusion in ExocytosisR01DK027044 · NIDDK · YALE UNIVERSITY · PI KRISHNAKUMAR, SHYAM S · 1986 to 2021
$8.2M
MECHANISMS OF INTRACELLULAR MEMBRANE FUSIONR37DK027044 · NIDDK · YALE UNIVERSITY · PI ROTHMAN, JAMES · 1992 to 2012
$5.3M
Regulation of Vesicle TrafficR35GM118084 · NIGMS · YALE UNIVERSITY · PI ROTHMAN, JAMES · 2016 to 2019
$3.4M
Structural basis of motility by dimeric kinesin motor proteinsR01GM110530 · NIGMS · YALE UNIVERSITY · PI SINDELAR, CHARLES VAUGHN · 2014 to 2023
$3.0M
NIDDK NIH HHS R01 DK027044NIDDK NIH HHS R37 DK027044NIGMS NIH HHS R01 GM110530NIGMS NIH HHS R35 GM118084
6 · The paper itself

Abstract

Previously, we showed that synaptotagmin1 (Syt1) forms Ca

Indexed as

Adenosine TriphosphateAmino Acid SequenceCations, DivalentCloning, MolecularEscherichia coliGene ExpressionGenetic VectorsInositol 1,4,5-TrisphosphateMagnesiumPhosphatidylinositol 4,5-DiphosphateProtein MultimerizationRecombinant Fusion ProteinsSynaptic VesiclesSynaptotagmin IAdenosine TriphosphateCations, DivalentInositol 1,4,5-TrisphosphateMagnesiumPhosphatidylinositol 4,5-DiphosphateRecombinant Fusion ProteinsSynaptotagmin ISYT1 protein, humanE. colielectron microscopymembrane fusionneuroscienceneurotransmitters

Identifiers

PMID28850328
PMCPMC5576491
OpenAlexW2751808509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.