Evidence map›Paper›PMID 28850113›Full record

ArticleTranslational psychiatry2017

PET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia.

M A Di Biase, A Zalesky, G O'keefe, L Laskaris, B T Baune, C S Weickert, J Olver, P D McGorry, G P Amminger, B Nelson and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Mismatch negativity matures in adolescence and without sensitivity to microglial depletion.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
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  13. Review
  14. Article
  15. Review
  16. Stress, Environment and Early Psychosis.Current neuropharmacology · 2024
    Review
  17. Review
  18. Microglia-neuron interactions in schizophrenia.Frontiers in cellular neuroscience · 2024
    Review
  19. Article
  20. Animal Models of Relevance to the Schizophrenia Prodrome.Biological psychiatry global open science · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

M A Di BiaseMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.
A ZaleskyMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.
G O'keefeDepartment of Molecular Imaging and Therapy, The University of Melbourne, Heidelberg, VIC Australia.
L LaskarisMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.
B T BauneDiscipline of Psychiatry, The University of Adelaide, Adelaide, SA, Australia.
C S WeickertMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.
J OlverDepartment of Psychiatry, The University of Melbourne, Parkville, VIC Australia.
P D McGorryOrygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia.
G P AmmingerOrygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia.
B NelsonOrygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia.
A M ScottDepartment of Molecular Imaging and Therapy, The University of Melbourne, Heidelberg, VIC Australia.
I HickieBrain &Mind Centre, The University of Sydney, Camperdown, NSW, Australia.
R BanatiMedical Radiation Sciences, The University of Sydney, Camperdown, NSW, Australia.
F TurkheimerDepartment of Neuroimaging, King's College London, London, UK.
M YaqubVU University Medical Center, Amsterdam, The Netherlands.
I P EverallDepartment of Psychiatry, The University of Melbourne, Parkville, VIC Australia.
C PantelisMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.
V CropleyMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.

Funding

Medical Research Council G0900891Medical Research Council G1100809Medical Research Council MC_U120085814Medical Research Council MR/K022733/1Medical Research Council MR/N026063/1
6 · The paper itself

Abstract

We examined putative microglial activation as a function of illness course in schizophrenia. Microglial activity was quantified using [

Indexed as

AdolescentAdultBrainCarbon RadioisotopesFemaleHumansIsoquinolinesMaleMicrogliaPositron-Emission TomographyPsychotic DisordersReceptors, GABARisk FactorsSchizophreniaYoung AdultCarbon-11Carbon RadioisotopesIsoquinolinesPK 11195Receptors, GABATSPO protein, human

Identifiers

PMID28850113
PMCPMC5611755

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.