Evidence map›Paper›PMID 28850106›Full record

ArticleScientific data2017

FANTOM5 CAGE profiles of human and mouse samples.

Shuhei Noguchi, Takahiro Arakawa, Shiro Fukuda, Masaaki Furuno, Akira Hasegawa, Fumi Hori, Sachi Ishikawa-Kato, Kaoru Kaida, Ai Kaiho, Mutsumi Kanamori-Katayama and 168 more

Abstract readDataset
In one paragraph

Article in Scientific data, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
190citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

190 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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130 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

178 authors.

Shuhei NoguchiDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Takahiro ArakawaDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Shiro FukudaRIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.
Masaaki FurunoDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Akira HasegawaDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Fumi HoriDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Sachi Ishikawa-KatoDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Kaoru KaidaRIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.
Ai KaihoRIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.
Mutsumi Kanamori-KatayamaRIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.
Tsugumi KawashimaDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Miki KojimaDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Atsutaka KubosakiRIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.
Ri-Ichiroh ManabeDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Mitsuyoshi MurataDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Sayaka Nagao-SatoDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Kenichi NakazatoRIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.
Noriko NinomiyaRIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.
Hiromi Nishiyori-SuekiDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Shohei NomaDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Eri SaijyoRIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.
Akiko SakaRIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.
Mizuho SakaiDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Christophe SimonRIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.
Naoko SuzukiDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Michihira TagamiDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Shoko WatanabeDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Shigehiro YoshidaRIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.
Peter ArnerDepartment of Medicine, Karolinska Institutet, 141 86, Stockholm, Sweden.
Richard A AxtonScottish Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK.
Magda BabinaDepartment of Dermatology and Allergy, Charite University Medicine Berlin, Charitéplatz 1, 10117 Berlin, German.
J Kenneth BaillieThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Midlothian EH25 9RG, UK.
Timothy C BarnettAustralian Infectious Diseases Research Centre, The University of Queensland, St Lucia, QLD 4072, Australia.
Anthony G BeckhouseBio-Rad Laboratories Pty Ltd, Hercules, California 94547, USA.
Antje BlumenthalThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102 Australia.
Beatrice BodegaIRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64, 00143 Rome, Italy.
Alessandro BonettiDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
James BriggsAustralian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, St Lucia, QLD 4072, Australia.
Frank BrombacherDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.
Ailsa J CarlisleThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Midlothian EH25 9RG, UK.
Hans C CleversHubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.
Carrie A DavisGenomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11797, USA.
Michael DetmarInstitute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 3, HCI H 303, 8093 Zurich, Switzerland.ORCID 0000-0002-5351-5054
Taeko DohiGastroenterology, Research Center for Hepatitis and Immunology, Research Institute National Center for Global Health and Medicine, Ichikawa, Chiba 272-8516, Japan.
Albert S B EdgeDepartment of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA.
Matthias EdingerDepartment of Internal Medicine III, University Hospital Regensburg, F.-J.-Strauss Allee 11, D-93053 Regensburg, Germany.
Anna EhrlundDepartment of Medicine, Karolinska Institutet, 141 86, Stockholm, Sweden.
Karl EkwallDepartment of Biosciences and Nutrition, Karolinska Institutet, Halsovagen 7-9, SE-141 83 Huddinge, Sweden.
Mitsuhiro EndohRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
Hideki EnomotoLaboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Chuou-ku, Kobe 650-0047, Japan.
Afsaneh EslamiDepartment of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan.
Michela FagioliniF.M. Kirby Neurobiology Center, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Lynsey FairbairnThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Midlothian EH25 9RG, UK.
Mary C Farach-CarsonThe University of Texas Health Science Center at Houston, Houston, TX 77251-1892, USA.ORCID 0000-0002-4526-3088
Geoffrey J FaulknerCancer Biology Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia.
Carmelo FerraiBerlin Institute for Medical Systems Biology, Max Delbrueck Center, Robert Roessle Str.10, 13125 Berlin, Germany.
Malcolm E FisherThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Midlothian EH25 9RG, UK.ORCID 0000-0003-1074-8103
Lesley M ForresterScottish Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK.ORCID 0000-0002-9717-8299
Rie FujitaDepartment of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan.
Jun-Ichi FurusawaRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
Teunis B GeijtenbeekExperimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Thomas GingerasGenomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11797, USA.
Daniel GoldowitzDepartment of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Sven GuhlDepartment of Dermatology and Allergy, Charite University Medicine Berlin, Charitéplatz 1, 10117 Berlin, German.
Reto GulerDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.
Stefano GustincichNeuroscience, SISSA, Via Bonomea 265, 34136 Trieste, Italy.
Thomas J HaDepartment of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Masahide HamaguchiDepartment of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.
Mitsuko HaraRIKEN Center for Life Science Technologies, Wako, Saitama 351-0198, Japan.
Yuki HasegawaDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Meenhard HerlynMelanoma Research Center, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Peter HeutinkGerman Center for Neurodegenerative Diseases (DZNE)-Tübingen, Otfried Müller Straße 23, 72076 Tübingen, Germany.ORCID 0000-0001-5218-1737
Kelly J HitchensAustralian Infectious Diseases Research Centre, The University of Queensland, St Lucia, QLD 4072, Australia.
David A HumeThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Midlothian EH25 9RG, UK.
Tomokatsu IkawaRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
Yuri IshizuDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Chieko KaiLaboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Hiroshi KawamotoRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
Yuki I KawamuraGastroenterology, Research Center for Hepatitis and Immunology, Research Institute National Center for Global Health and Medicine, Ichikawa, Chiba 272-8516, Japan.
Judith S KempfleDepartment of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA.
Tony J KennaInstitute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia.
Juha KereDepartment of Biosciences and Nutrition, Karolinska Institutet, Halsovagen 7-9, SE-141 83 Huddinge, Sweden.ORCID 0000-0003-1974-0271
Levon M KhachigianCentre for Vascular Research, University of New South Wales, Sydney, New South Wales 2052, Australia.
Toshio KitamuraDivision of Cellular Therapy and Division of Stem Cell Signaling, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Sarah KleinInstitute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 3, HCI H 303, 8093 Zurich, Switzerland.
S Peter KlinkenHarry Perkins Institute of Medical Research, Perth, WA 6009, Australia.
Alan J KnoxRespiratory Medicine, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK.
Soichi KojimaRIKEN Center for Life Science Technologies, Wako, Saitama 351-0198, Japan.ORCID 0000-0002-5252-1612
Haruhiko KosekiRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
Shigeo KoyasuRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
Weonju LeeDermatology, School of Medicine Kyungpook National University, Jung-gu, Daegu 41944, Korea.
Andreas LennartssonDepartment of Biosciences and Nutrition, Karolinska Institutet, Halsovagen 7-9, SE-141 83 Huddinge, Sweden.
Alan Mackay-SimGriffith University, Brisbane, Queensland 4111, Australia.
Niklas MejhertDepartment of Medicine, Karolinska Institutet, 141 86, Stockholm, Sweden.
Yosuke MizunoDivision of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama 350-1241, Japan.
Hiromasa MorikawaDepartment of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.ORCID 0000-0002-6793-5885
Mitsuru MorimotoLaboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Chuou-ku, Kobe 650-0047, Japan.
Kazuyo MoroRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
Kelly J MorrisBerlin Institute for Medical Systems Biology, Max Delbrueck Center, Robert Roessle Str.10, 13125 Berlin, Germany.
Hozumi MotohashiCenter for Radioisotope Sciences, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan.
Christine L MummeryAnatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
Yutaka NakachiDivision of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama 350-1241, Japan.
Fumio NakaharaDivision of Cellular Therapy and Division of Stem Cell Signaling, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Toshiyuki NakamuraLaboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Yukio NakamuraCell Engineering Division, RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074, Japan.
Tadasuke NozakiDepartment of Clinical Molecular Genetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.
Soichi OgishimaDepartment of Bioclinical Informatics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi 980-8573, Japan.
Naganari OhkuraDepartment of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.
Hiroshi OhnoRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
Mitsuhiro OhshimaDepartment of Biochemistry, Ohu University School of Pharmaceutical Sciences, Koriyama, Fukushima 963-8611 Japan.
Mariko Okada-HatakeyamaRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
Yasushi OkazakiDivision of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama 350-1241, Japan.
Valerio OrlandoIRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64, 00143 Rome, Italy.
Dmitry A OvchinnikovAustralian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, St Lucia, QLD 4072, Australia.
Robert PassierAnatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
Margaret PatrikakisCentre for Vascular Research, University of New South Wales, Sydney, New South Wales 2052, Australia.
Ana PomboBerlin Institute for Medical Systems Biology, Max Delbrueck Center, Robert Roessle Str.10, 13125 Berlin, Germany.ORCID 0000-0002-7493-6288
Swati Pradhan-BhattUniversity of Delaware, Newark, DE 19716 USA.
Xian-Yang QinRIKEN Center for Life Science Technologies, Wako, Saitama 351-0198, Japan.
Michael RehliDepartment of Internal Medicine III, University Hospital Regensburg, F.-J.-Strauss Allee 11, D-93053 Regensburg, Germany.
Patrizia RizzuGerman Center for Neurodegenerative Diseases (DZNE)-Tübingen, Otfried Müller Straße 23, 72076 Tübingen, Germany.
Sugata RoyRIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.
Antti SajantilaHjelt Institute, Department of Forensic Medicine, University of Helsinki, Kytosuontie 11, 003000 Helsinki, Finland.
Shimon SakaguchiDepartment of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.
Hiroki SatoLaboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Hironori SatohDepartment of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan.
Suzana SavviDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.
Alka SaxenaRIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.
Christian SchmidlDepartment of Internal Medicine III, University Hospital Regensburg, F.-J.-Strauss Allee 11, D-93053 Regensburg, Germany.
Claudio SchneiderLaboratorio Nazionale CIB, Padriciano, 99 34149, Trieste, Italy.
Gundula G Schulze-TanzilDepartment of Orthopedic, Trauma and Reconstructive Surgery, Charite Universitatsmedizin Berlin, Charitéplatz 1, 10117 Berlin, German.
Anita SchwegmannDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.
Guojun ShengInternational Research Center for Medical Sciences (IRCMS), Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan.
Jay W ShinDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Daisuke SugiyamaDepartment of Clinical Study, Center for Advanced Medical Innovation, Kyushu University, Higashi-Ku, Fukuoka 812-8582, Japan.
Takaaki SugiyamaLaboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Kim M SummersThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Midlothian EH25 9RG, UK.
Naoko TakahashiRIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.
Jun TakaiDepartment of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan.
Hiroshi TanakaDepartment of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan.
Hideki TatsukawaGraduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, Aichi 464-8601, Japan.
Andru TomoiuThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Midlothian EH25 9RG, UK.
Hiroo ToyodaCenter for Radioisotope Sciences, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan.
Marc van de WeteringHubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.
Linda M van den BergExperimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Roberto VerardoLaboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie (LNCIB), Padriciano 99, 34149 Trieste, Italy.
Dipti VijayanQIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Christine A WellsCentre for Stem Cell Systems, Department of Anatomy and Neuroscience, MDHS, University of Melbourne, Melbourne, VIC 3010, Australia.
Louise N WinteringhamHarry Perkins Institute of Medical Research, Perth, WA 6009, Australia.
Ernst WolvetangAustralian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, St Lucia, QLD 4072, Australia.
Yoko YamaguchiDepartment of Biochemistry, Nihon University School of Dentistry, Chiyoda-ku, Tokyo 101-8310, Japan.
Masayuki YamamotoDepartment of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan.
Chiyo Yanagi-MizuochiCenter for Clinical and Translational Reseach, Kyushu University Hospital, Higashi-Ku, Fukuoka 812-8582, Japan.
Misako YonedaLaboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Yohei YonekuraLaboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Chuou-ku, Kobe 650-0047, Japan.
Peter G ZhangDepartment of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
Silvia ZucchelliNeuroscience, SISSA, Via Bonomea 265, 34136 Trieste, Italy.
Imad AbugessaisaDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.ORCID 0000-0001-7458-801X
Erik ArnerDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Jayson HarshbargerDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Atsushi KondoDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Timo LassmannDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Marina LizioDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.ORCID 0000-0001-7337-7325
Serkan SahinDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Thierry SengstagRIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.
Jessica SeverinDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Hisashi ShimojiRIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.
Masanori SuzukiRIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.
Harukazu SuzukiDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Jun KawaiRIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.
Naoto KondoDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Masayoshi ItohDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Carsten O DaubDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Takeya KasukawaDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.ORCID 0000-0001-5085-0802
Hideya KawajiDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.ORCID 0000-0002-0575-0308
Piero CarninciDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Alistair R R ForrestDivision of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, Japan.
Yoshihide HayashizakiRIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9M
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2M
Wnt Signaling in Hair Cell Generation from Supporting CellsR01DC014089 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI EDGE, ALBERT · 2016 to 2020
$1.8M
Training and Education ProgramP20CA192996 · NCI · COLD SPRING HARBOR LABORATORY · PI MCCOMBIE, WILLIAM RICHARD · 2015 to 2018
$620k
Biotechnology and Biological Sciences Research Council BB/H008098/1Biotechnology and Biological Sciences Research Council BBS/E/D/20211550Biotechnology and Biological Sciences Research Council BBS/E/D/20211551Biotechnology and Biological Sciences Research Council BBS/E/D/20211552Medical Research Council MC_U120061476NCI NIH HHS P20 CA192996NCI NIH HHS P30 CA010815NCI NIH HHS P30 CA045508NICHD NIH HHS U54 HD090255NIDCD NIH HHS R01 DC014089
6 · The paper itself

Abstract

In the FANTOM5 project, transcription initiation events across the human and mouse genomes were mapped at a single base-pair resolution and their frequencies were monitored by CAGE (Cap Analysis of Gene Expression) coupled with single-molecule sequencing. Approximately three thousands of samples, consisting of a variety of primary cells, tissues, cell lines, and time series samples during cell activation and development, were subjected to a uniform pipeline of CAGE data production. The analysis pipeline started by measuring RNA extracts to assess their quality, and continued to CAGE library production by using a robotic or a manual workflow, single molecule sequencing, and computational processing to generate frequencies of transcription initiation. Resulting data represents the consequence of transcriptional regulation in each analyzed state of mammalian cells. Non-overlapping peaks over the CAGE profiles, approximately 200,000 and 150,000 peaks for the human and mouse genomes, were identified and annotated to provide precise location of known promoters as well as novel ones, and to quantify their activities.

Indexed as

Gene Expression ProfilingGenomeAnimalsGene Expression RegulationHumansMicePromoter Regions, GeneticSpecies Specificity

Identifiers

PMID28850106
PMCPMC5574368

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