Evidence map›Paper›PMID 28849698›Full record

ArticleMolecular imaging

Imaging Neurotensin Receptor in Prostate Cancer With

Huaifu Deng, Hui Wang, He Zhang, Mengzhe Wang, Ben Giglio, Xiaofen Ma, Guihua Jiang, Hong Yuan, Zhanhong Wu, Zibo Li

Open access · goldAbstract read
In one paragraph

Article in Molecular imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Neurotensin and Its Involvement in Female Hormone-Sensitive Cancers.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Chelator boosted tumor-retention and pharmacokinetic properties: development ofEuropean journal of nuclear medicine and molecular imaging · 2024
    Article
  7. Synthesis ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  8. Article
  9. Article
  10. Preclinical PET Imaging of NTSR-1-Positive Tumors withCancer biotherapy & radiopharmaceuticals · 2021
    Article
  11. Pancreatic Ductal Adenocarcinoma: The Dawn of the Era of Nuclear Medicine?International journal of molecular sciences · 2021
    Review
  12. Article
  13. Review
  14. Review
  15. Evaluation of neurotensin receptor 1 as potential biomarker for prostate cancer theranostic use.European journal of nuclear medicine and molecular imaging · 2019
    Article
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Huaifu Deng1 Department of Radiology, Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Hui Wang1 Department of Radiology, Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
He Zhang1 Department of Radiology, Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Mengzhe Wang1 Department of Radiology, Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ben Giglio1 Department of Radiology, Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Xiaofen Ma1 Department of Radiology, Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Guihua Jiang4 Department of Medical Imaging, Provincial People's Hospital, Guangzhou, China.
Hong Yuan1 Department of Radiology, Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Zhanhong Wu1 Department of Radiology, Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Zibo Li1 Department of Radiology, Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Imaging Center · USUniversity of North Carolina at Chapel Hill · USFirst Affiliated Hospital of Guangzhou Medical University · CNGuangdong Provincial People's Hospital · CN

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
NCI NIH HHS P30 CA016086
6 · The paper itself

Abstract

introductionNeurotensin receptor 1 (NTR-1) is expressed and activated in prostate cancer cells. In this study, we explore the NTR expression in normal mouse tissues and study the positron emission tomography (PET) imaging of NTR in prostate cancer models. MATERIALS AND

methodsThree

resultsAll 3 NT conjugates retained the majority of NTR binding affinity. In HT-29 tumor, all agents demonstrated prominent tumor uptake. Although comparable stability was observed,

conclusionsOur results demonstrated that

Indexed as

Copper RadioisotopesHeterocyclic CompoundsHeterocyclic Compounds, 1-RingHT29 CellsHumansMaleNeurotensinPositron-Emission TomographyProstatic NeoplasmsReceptors, Neurotensin1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid1,4,7-triazacyclononane-N,N',N''-triacetic acidCopper RadioisotopesHeterocyclic CompoundsHeterocyclic Compounds, 1-RingNeurotensinReceptors, Neurotensin64Cuneurotensin receptor 1 (NTR-1)positron emission tomography (PET)prostate cancer

Identifiers

PMID28849698
PMCPMC6081756
OpenAlexW2751725132

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.