Evidence map›Paper›PMID 28849572›Full record

ReviewMethods in molecular biology (Clifton, N.J.)2017

Pharmacologic Manipulation of Wnt Signaling and Cancer Stem Cells.

Yann Duchartre, Yong-Mi Kim, Michael Kahn

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Methods in molecular biology (Clifton, N.J.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. ST6Gal1: Oncogenic signaling pathways and targets.Frontiers in molecular biosciences · 2022
    Review
  2. Article
  3. Wnt Signaling in Leukemia and Its Bone Marrow Microenvironment.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yann DuchartreDivision of Hematology and Oncology, Department of Pediatrics and Pathology, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Yong-Mi KimDivision of Hematology and Oncology, Department of Pediatrics and Pathology, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Michael KahnDepartment of Biochemistry and Molecular Biology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA. kahnm@med.usc.edu.

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Understanding the niche of minimal residual disease leukemia cellsR01CA172896 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI KIM, YONG-MI · 2013 to 2022
$3.7M
Efficacy of Novel Wnt Modulator in Colon CancerR01CA166161 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KAHN, MICHAEL, LENZ, HEINZ JOSEF · 2013 to 2017
$2.3M
Mechanisms of beta-catenin signaling in alveolar epithelial cell differentiationR01HL112638 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BOROK, ZEA, KAHN, MICHAEL · 2013 to 2016
$2.2M
Modulation of Wnt Signaling in Models of Multiple SclerosisR21NS074392 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GILMORE, WENDY · 2012 to 2013
$444k
Innate enteric immunity during induced Paneth cell deficiencyR21AI105057 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OUELLETTE, ANDRE J. · 2013 to 2014
$440k
NCI NIH HHS P30 CA014089NCI NIH HHS R01 CA166161NCI NIH HHS R01 CA172896NHLBI NIH HHS R01 HL112638NIAID NIH HHS R21 AI105057NINDS NIH HHS R21 NS074392
6 · The paper itself

Abstract

Wnt (Wingless-related integration site)-signaling orchestrates self-renewal programs in normal somatic stem cells as well as in cancer stem cells. Aberrant Wnt signaling is associated with a wide variety of malignancies and diseases. Although our understanding has increased tremendously over the past decade, therapeutic targeting of the dysregulated Wnt pathway remains a challenge. Here we review recent preclinical and clinical therapeutic approaches to target the Wnt pathway.

Indexed as

AnimalsAntineoplastic AgentsClinical Trials as TopicHumansMolecular Targeted TherapyNeoplasmsNeoplastic Stem CellsWnt Signaling PathwayXenograft Model Antitumor AssaysAntineoplastic AgentsCancer stem cellsClinical trialDrug resistanceSelf-renewalSomatic stem cellsWnt signaling

Identifiers

PMID28849572
PMCPMC7473415

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.