ArticleAdvances in experimental medicine and biology
Taurine Ameliorates Arsenic-Induced Apoptosis in the Hippocampus of Mice Through Intrinsic Pathway.
Article in Advances in experimental medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The Protective Effects of Taurine, a Non-essential Amino Acid, Against Metals Toxicities: A Review Article.Biological trace element research · 2025Review
- Minocycline as a Neuroprotective Agent in Arsenic-Induced Neurotoxicity in PC12 Cells.Biological trace element research · 2023Article
- Arsenic Induces Differential Neurotoxicity in Male, Female, and E2-Deficient Females: Comparative Effects on Hippocampal Neurons and Cognition in Adult Rats.Molecular neurobiology · 2022Article
- Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes.Nutrients · 2022Review
- Taurine and Astrocytes: A Homeostatic and Neuroprotective Relationship.Frontiers in molecular neuroscience · 2022Review
- Influences of Taurine Pharmacodynamics and Sex on Active Avoidance Learning and Memory.Advances in experimental medicine and biology · 2022Article
- Taurine as a Natural Antioxidant: From Direct Antioxidant Effects to Protective Action in Various Toxicological Models.Antioxidants (Basel, Switzerland) · 2021Review
- Taurine protects noradrenergic locus coeruleus neurons in a mouse Parkinson's disease model by inhibiting microglial M1 polarization.Amino acids · 2018Article
- Taurine protects dopaminergic neurons in a mouse Parkinson's disease model through inhibition of microglial M1 polarization.Cell death & disease · 2018Article
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Authors and funding
8 authors.
Funding
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Abstract
Our group previously reported that arsenic (As) exposure induced apoptosis in hippocampus neurons. The aim of the present study was to clarify the protective capacity of taurine (Tau) on As-induced neuronal apoptosis and the related mechanism in mouse hippocampus. Mice were divided into: control group, Tau control group, As exposure group and Tau protective group, randomly. The apoptotic rate of mouse hippocampus was determined by TUNEL staining. The levels of Bcl-2 and Bax gene and protein were analyzed by real time RT-PCR and WB, respectively. Furthermore, cytochrome c (Cyt C) release, and the activity of caspase-8 and caspase-3 were also determined. The results showed that Tau treatment induced the decrease of TUNEL-positive cells, prohibited the disturbance of Bcl-2 and Bax expression, and inhibited Cyt C release and caspase-8 and caspase-3 activation significantly. The results indicated that Tau supplement markedly ameliorates As-induced apoptosis by mitochondria-related pathway in mouse hippocampus.
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Registered trials
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