Evidence map›Paper›PMID 28849366›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2017

Is Adjuvant Therapy Necessary for All Patients with Localized Pancreatic Cancer Who Have Received Neoadjuvant Therapy?

Chad A Barnes, Ashley N Krepline, Mohammed Aldakkak, Callisia N Clarke, Kathleen K Christians, Abdul H Khan, Bryan C Hunt, Paul S Ritch, Ben George, William A Hall and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  9. Article
  10. Borderline resectable pancreatic cancer: Certainties and controversies.World journal of gastrointestinal surgery · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Chad A BarnesPancreatic Cancer Program, Department of Surgery, The Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI, 53226, USA.
Ashley N KreplinePancreatic Cancer Program, Department of Surgery, The Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI, 53226, USA.
Mohammed AldakkakPancreatic Cancer Program, Department of Surgery, The Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI, 53226, USA.
Callisia N ClarkePancreatic Cancer Program, Department of Surgery, The Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI, 53226, USA.
Kathleen K ChristiansPancreatic Cancer Program, Department of Surgery, The Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI, 53226, USA.
Abdul H KhanPancreatic Cancer Program, Department of Gastroenterology, The Medical College of Wisconsin, Milwaukee, WI, USA.
Bryan C HuntPancreatic Cancer Program, Department of Pathology, The Medical College of Wisconsin, Milwaukee, WI, USA.
Paul S RitchPancreatic Cancer Program, Department of Medical Oncology, The Medical College of Wisconsin, Milwaukee, WI, USA.
Ben GeorgePancreatic Cancer Program, Department of Medical Oncology, The Medical College of Wisconsin, Milwaukee, WI, USA.
William A HallPancreatic Cancer Program, Department of Radiation Oncology, The Medical College of Wisconsin, Milwaukee, WI, USA.
Beth A EricksonPancreatic Cancer Program, Department of Radiation Oncology, The Medical College of Wisconsin, Milwaukee, WI, USA.
Douglas B EvansPancreatic Cancer Program, Department of Surgery, The Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI, 53226, USA.
Susan TsaiPancreatic Cancer Program, Department of Surgery, The Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI, 53226, USA. stsai@mcw.edu.
Medical College of Wisconsin · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmong patients with localized pancreatic cancer (PC), the benefit of adjuvant therapy after neoadjuvant therapy and surgery is unknown.

methodsPatients with localized PC who completed all intended neoadjuvant therapy and surgery were categorized based on the receipt of adjuvant therapy and by pathologic lymph node status (LN

resultsData was available from 234 consecutive patients, 121 (52%) with resectable and 113 (48%) with borderline resectable PC. Of the 234 patients, 92 (39%) were LN

conclusionAmong patients with localized PC who received neoadjuvant therapy and surgery, the benefit of adjuvant therapy was limited to those with node-positive disease.

Indexed as

PancreatectomyAgedAntineoplastic AgentsCombined Modality TherapyFemaleHumansMaleMiddle AgedPancreatic NeoplasmsPatient SelectionProportional Hazards ModelsRetrospective StudiesTreatment OutcomeAntineoplastic AgentsAdjuvant therapyLymph nodeNeoadjuvant therapyPancreatic cancer

Identifiers

PMID28849366
OpenAlexW2748502848

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.