AMP-activated protein kinase and cAMP response element-binding protein activity are associated with distinct postoperative behavioral changes in rats.

Dan Li, Feng Ye, Wen Ouyang, Yi Wang

Abstract read

In one paragraph

Article in Journal of anesthesia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0 citing papers in PubMed, 1 citations in OpenAlex.

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5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Dan LiDepartment of Anesthesiology, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha, 410013, Hunan, People's Republic of China.

Feng YeKey Laboratory of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital, Ministry of Education of China, Chongqing Medical University, Chongqing, 400010, China.

Wen OuyangDepartment of Anesthesiology, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha, 410013, Hunan, People's Republic of China.

Yi WangDepartment of Anesthesiology, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha, 410013, Hunan, People's Republic of China. mzk841230@126.com.

Third Xiangya Hospital · CNDalian Medical University · CN

Funding

National Natural Science Foundation of China 31270028National Natural Science Foundation of China 81500932

6 · The paper itself

Abstract

purposeTo explore the association of AMP-activated protein kinase (AMPK) and cAMP response element-binding protein (CREB) activity with distinct postoperative behavioral changes in rats.

methodsWe performed partial hepatolobectomy in adult rats and aged rats. The learning and memory ability of rats was evaluated by the Barnes maze test on postoperative days 1-4. The expressions of AMPK and phosphorylated CREB (p-CREB) in the CA1 and DG regions of the hippocampus were detected by immunohistochemical assay at 3, 6, 12 and 24 h postoperatively.

resultsSurgery impaired the memory of aged rats but not that of adult rats on postoperative days 2 and 3 (both p < 0.05). Surgery synergistically increased the expressions of AMPK and p-CREB in the CA1 region of hippocampus in aged rats but not in adult rats at 3 and 6 h postoperatively.

conclusionOur data suggest that surgery induces cognitive impairment in aged rats. Surgery-induced expression of AMPK and p-CREB in the CA1 region of hippocampus may be involved in this cognitive impairment.

Indexed as

AMP-Activated Protein KinasesAnimalsCyclic AMP Response Element-Binding ProteinFemaleHippocampusLearningMaleMemoryPhosphorylationRatsRats, Sprague-DawleyAMP-Activated Protein KinasesCyclic AMP Response Element-Binding ProteinAMP-activated protein kinasecAMP response element-binding proteinPostoperative cognitive dysfunction

Identifiers

PMID28849288

DOI10.1007/s00540-017-2398-z

OpenAlexW2747378846

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.