Evidence map›Paper›PMID 28849079›Full record

ArticleMolecular medicine reports2017

Betaine attenuates chronic alcohol‑induced fatty liver by broadly regulating hepatic lipid metabolism.

Wenjuan Yang, Luming Huang, Jinhang Gao, Shilei Wen, Yang Tai, Meng Chen, Zhiyin Huang, Rui Liu, Chengwei Tang, Jing Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 57 citations in OpenAlex.

  1. [Alcoholic liver disease: new insights into an undeniable challenge and strategies for prevention and treatment].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
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  20. Amino acid metabolism in health and disease.Signal transduction and targeted therapy · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Wenjuan YangDepartment of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Luming HuangDepartment of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Jinhang GaoDivision of Peptides Related with Human Diseases, State Key Laboratory of Biotherapy, Chengdu, Sichuan 610000, P.R. China.
Shilei WenDivision of Peptides Related with Human Diseases, State Key Laboratory of Biotherapy, Chengdu, Sichuan 610000, P.R. China.
Yang TaiDepartment of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Meng ChenDepartment of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Zhiyin HuangDepartment of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Rui LiuDivision of Peptides Related with Human Diseases, State Key Laboratory of Biotherapy, Chengdu, Sichuan 610000, P.R. China.
Chengwei TangDepartment of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Jing LiDepartment of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
West China Hospital of Sichuan University · CNState Key Laboratory of BiotherapySichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Betaine has previously been demonstrated to protect the liver against alcohol‑induced fat accumulation. However, the mechanism through which betaine affects alcohol‑induced hepatic lipid metabolic disorders has not been extensively studied. The present study aimed to investigate the effect of betaine on alcoholic simple fatty liver and hepatic lipid metabolism disorders. A total of 36 rats were randomly divided into control, ethanol and ethanol + betaine groups. Liver function, morphological alterations, lipid content and tumor necrosis factor (TNF)‑α levels were determined. Hepatic expression levels of diacylglycerol acyltransferase (DGAT) 1, DGAT2, sterol regulatory element binding protein (SREBP)‑1c, SREBP‑2, fatty acid synthase (FAS), 3‑hydroxy‑3‑methyl‑glutaryl (HMG)‑CoA reductase, peroxisome proliferator-activated receptor λ coactivator (PGC)‑1α, adiponectin receptor (AdipoR) 1 and AdipoR2 were quantified. Serum and adipose tissue adiponectin levels were assessed using an enzyme‑linked immunoassay. The results demonstrated that alcohol‑induced ultramicrostructural alterations in hepatocytes, including the presence of lipid droplets and swollen mitochondria, were attenuated by betaine. Hepatic triglyceride, free fatty acid, total cholesterol and cholesterol ester contents and the expression of DGAT1, DGAT2, SREBP‑1c, SREBP‑2, FAS and HMG‑CoA reductase were increased following ethanol consumption, however were maintained at control levels following betaine supplementation. Alcohol‑induced decreases in hepatic PGC‑1α mRNA levels and serum and adipose tissue adiponectin concentrations were prevented by betaine. The downregulation of hepatic AdipoR1 which resulted from alcohol exposure was partially attenuated by betaine. No significant differences in liver function, TNF‑α, phospholipid and AdipoR2 levels were observed among the control, ethanol and ethanol + betaine groups. Overall, these results indicated that betaine attenuated the alcoholic simple fatty liver by improving hepatic lipid metabolism via suppression of DGAT1, DGAT2, SREBP‑1c, FAS, SREBP‑2 and HMG‑CoA reductase and upregulation of PGC‑1α.

Indexed as

AdiponectinAlcohol DrinkingAnimalsBetaineDiacylglycerol O-AcyltransferaseFatty Acid SynthasesFatty Liver, AlcoholicHepatocytesHydroxymethylglutaryl CoA ReductasesLipid MetabolismLiverMaleNutritional StatusPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaRats, WistarReceptors, AdiponectinAdiponectinBetaineDiacylglycerol O-AcyltransferaseFatty Acid SynthasesHydroxymethylglutaryl CoA ReductasesPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaReceptors, AdiponectinSterol Regulatory Element Binding Protein 1Tumor Necrosis Factor-alpha

Identifiers

PMID28849079
PMCPMC5647077
OpenAlexW2576528277

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.