ArticleJournal of materials chemistry. B2017
A General Strategy for Generating Gradients of Bioactive Proteins on Electrospun Nanofiber Mats by Masking with Bovine Serum Albumin.
Article in Journal of materials chemistry. B, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Functionally Graded Surfaces and Materials: From Fabrication to Biomedical Applications.Chemical reviews · 2026Review
- Rational Fabrication of Functionally-Graded Surfaces for Biological and Biomedical Applications.Accounts of materials research · 2024Article
- Electrospun hydrogels for dynamic culture systems: advantages, progress, and opportunities.Biomaterials science · 2021Review
- Multivalent Affinity Profiling: Direct Visualization of the Superselective Binding of Influenza Viruses.ACS nano · 2021Article
- Augmenting Tendon-to-Bone Repair with Functionally Graded Scaffolds.Advanced healthcare materials · 2021Review
- A Nanofiber Mat With Dual Bioactive Components and a Biomimetic Matrix Structure for Improving Osteogenesis Effect.Frontiers in chemistry · 2021Article
- A Comprehensive Review of the Covalent Immobilization of Biomolecules onto Electrospun Nanofibers.Nanomaterials (Basel, Switzerland) · 2020Review
- Promoting Cell Migration and Neurite Extension along Uniaxially Aligned Nanofibers with Biomacromolecular Particles in a Density Gradient.Advanced functional materials · 2020Article
- Engraving the Surface of Electrospun Microfibers with Nanoscale Grooves Promotes the Outgrowth of Neurites and the Migration of Schwann Cells.Angewandte Chemie (International ed. in English) · 2020Article
- Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications.Chemical reviews · 2019Review
- Ultraviolet Functionalization of Electrospun Scaffolds to Activate Fibrous Runways for Targeting Cell Adhesion.Frontiers in bioengineering and biotechnology · 2019Article
- Perspective: Aligned arrays of electrospun nanofibers for directing cell migration.APL materials · 2018Article
- General Method for Generating Circular Gradients of Active Proteins on Nanofiber Scaffolds Sought for Wound Closure and Related Applications.ACS applied materials & interfaces · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Electrospun nanofibers are widely used in tissue engineering owing to their capability to mimic the structures and architectures of various types of extracellular matrices. However, it has been difficult to incorporate a biochemical cue into the physical cue provided by the nanofibers. Here we report a simple and versatile method for generating gradients of bioactive proteins on nanofiber mats. We establish that the adsorption of bovine serum albumin (BSA) onto nanofibers is a time- and concentration-dependent process. By linearly increasing the volume of BSA solution introduced into a container, a gradient in BSA is readily generated across the length of a vertically oriented strip of nanofibers. Next, the bare regions uncovered by BSA can be filled with the bioactive protein of interest. In demonstrating the potential application, we examine the outgrowth of neurites from dorsal root ganglion (DRG) isolated from chick embryos and then seeded on aligned polycaprolactone nanofibers covered by nerve growth factor (NGF) with a uniform coverage or in a gradient. In the case of uniform coverage, the neurites extending from DRG show essentially the same length on either side of the DRG cell mass. For the sample with a gradient in NGF, the neurites extending along the gradient (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.