ArticleFrontiers in aging neuroscience2017
Age-Related Shift in Neuro-Activation during a Word-Matching Task.
Article in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Aging-related changes in cognitive flexibility: fMRI meta-analysis.Behavioral and brain functions : BBF · 2025Pooled it
- Mapping common and distinct brain correlates among cognitive flexibility tasks: concordant evidence from meta-analyses.Brain imaging and behavior · 2025Pooled it
- Cerebral pulsatility might be a driver of neurofunctional reorganization in the aging brain: an MRI and NIRS study.Frontiers in aging neuroscience · 2025Article
- Amelioration of age-related cognitive decline and anxiety in mice byFrontiers in aging · 2024Article
- Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction, and is required for the cognitive enhancing effects of Centella asiatica during aging.Neurobiology of aging · 2021Article
- Visual Perceptual Load Attenuates Age-Related Audiovisual Integration in an Audiovisual Discrimination Task.Frontiers in psychology · 2021Article
- Loss of NRF2 leads to impaired mitochondrial function, decreased synaptic density and exacerbated age-related cognitive deficits.Experimental gerontology · 2020Article
- Functional MRI on executive functioning in aging and dementia: A scoping review of cognitive tasks.Aging medicine (Milton (N.S.W)) · 2018Article
- Centella asiatica increases hippocampal synaptic density and improves memory and executive function in aged mice.Brain and behavior · 2018Article
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8 authors.
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Abstract
Growing evidence from the neuroscience of aging suggests that executive function plays a pivotal role in maintaining semantic processing performance. However, the presumed age-related activation changes that sustain executive semantic processing remain poorly understood. The aim of this study was to explore the executive aspects of semantic processing during a word-matching task with regard to age-related neuro-functional reorganization, as well as to identify factors that influence executive control profiles. Twenty younger and 20 older participants underwent fMRI scanning. The experimental task was based on word-matching, wherein visual feedback was used to instruct participants to either maintain or switch a semantic-matching rule. Response time and correct responses were assessed for each group. A battery of cognitive tests was administrated to all participants and the older group was divided into two subgroups based on their cognitive control profiles. Even though the percentage of correct responses was equivalent in the task performance between both groups and within the older groups, neuro-functional activation differed in frontoparietal regions with regards to age and cognitive control profiles. A correlation between behavioral measures (correct responses and response times) and brain signal changes was found in the left inferior parietal region in older participants. Results indicate that the shift in age-related activation from frontal to parietal regions can be viewed as another form of neuro-functional reorganization. The greater reliance on inferior parietal regions in the older compared to the younger group suggests that the executive control system is still efficient and sustains semantic processing in the healthy aging brain. Additionally, cognitive control profiles underlie executive ability differences in healthy aging appear to be associated with specific neuro-functional reorganization throughout frontal and parietal regions. These findings demonstrate that changes in neural support for executive semantic processing during a word-matching task are not only influenced by age, but also by cognitive control profile.
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