ArticleHIV/AIDS (Auckland, N.Z.)2017
Determinants of virological failure among patients on highly active antiretroviral therapy in University of Gondar Referral Hospital, Northwest Ethiopia: a case-control study.
Article in HIV/AIDS (Auckland, N.Z.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
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Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Factors associated with antiretroviral treatment failure among people living with HIV on antiretroviral therapy in resource-poor settings: a systematic review and metaanalysis.Systematic reviews · 2020Pooled it
- HIV/AIDS treatment failure and associated factors in Ethiopia: meta-analysis.BMC public health · 2020Pooled it
- Viral suppression status and associated factors among key populations on ART in Western Oromia, Ethiopia: a retrospective analysis.AIDS research and therapy · 2026Article
- Viral load suppression and associated factors among patients receiving ART in Mekelle, Ethiopia: a cross-sectional study.BMC infectious diseases · 2026Article
- Epidemiological characteristics of people living with HIV on antiretroviral therapy (ART) in Pointe-Noire, Republic of congo.BMC infectious diseases · 2026Article
- Predictors of longitudinal viral load suppression among adults receiving first line antiretroviral therapy in Central Ethiopia.Scientific reports · 2025Article
- Magnitude and factors associated with virological failure among adults on first-line antiretroviral therapy in Dire Dawa, eastern Ethiopia: a retrospective chart review.BMC research notes · 2025Article
- Observational
- Factors Associated with Viral Load Non-Suppression among People Living with HIV on Antiretroviral Therapy in Dili, Timor-Leste.Infection & chemotherapy · 2025Article
- Article
- Virological treatment failure and associated factors among adults on first-line antiretroviral therapy in West Hararghe, Ethiopia.Frontiers in public health · 2025Article
- Tracking viral control in adolescents on antiretroviral therapy in Lusaka, Zambia: A retrospective cohort analysis.Southern African journal of HIV medicine · 2025Article
- Viral load change and time to death among adult HIV/AIDS patients on ART after test-and-treat in Northwest Ethiopia: a retrospective multi-center follow-up study using Bayesian joint modeling.Frontiers in public health · 2025Article
- Prevalence of detectable viral load and its associated factors among adult patients receiving ART in Choma District, Zambia.PloS one · 2025Article
- Determinants of virologic failure among adult HIV patients on first line antiretroviral treatment in Oromia, Central Ethiopia: 2022 a case-control study.AIDS research and therapy · 2024Article
- Predictors of antiretroviral treatment failure to the first line therapy: a cross-sectional study among Iranian HIV-positive adults.BMC infectious diseases · 2024Article
- Epidemiological and virological characteristics of people living with HIV on antiretroviral treatment for more than 6 months in virological failure in Brazzaville, Republic of Congo.Access microbiology · 2024Article
- Factors linked to virological failure in people on a dolutegravir-based regimen in Mamelodi.Southern African journal of infectious diseases · 2024Article
- Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundViral load monitoring is used as an important biomarker for diagnosing treatment failure in patients with HIV infection/AIDS. Ethiopia has started targeted viral load monitoring. However, factors leading to virological failure are not well understood and studied. Thus, the aim of this study was to identify the determinants of virological failure among HIV-infected patients on highly active antiretroviral therapy at the University of Gondar Referral Hospital, Northwest Ethiopia.
methodsA case-control study was conducted from May to June 2015. Cases were subjects who had already experienced virological failure; controls were those without virological failure. Data were extracted from 153 cases and 153 controls through chart review. A multivariate logistic regression analysis was carried out to identify factors associated with virological failure, and variables with a
resultsIn this study, higher odds of virological failure was observed among patients aged <35 years (adjusted odds ratio [AOR] =2.52, 95% CI: 1.33, 4.77), who had had CD4+ count <200 cells/mm
conclusionThis study showed that patients aged <35 years and with recent low CD4 count, poor adherence to treatment, and longer exposure to ART were positively and significantly associated with virological treatment failure. Therefore, evidence-based intervention should be implemented to improve adherence to ART, which in turn helps to boost immunity (CD4) and suppresses viral replication and load. Moreover, attention should be given to younger patients who have had ART for longer periods.
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