ReviewInternational journal of chronic obstructive pulmonary disease2017
Small airways disease: time for a revisit?
Review in International journal of chronic obstructive pulmonary disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- The Relationship Between Gas Transfer Measurements, Lung Volumes, and Spirometric Indices in Alpha-1 Antitrypsin Deficiency and Non-AATD COPD: A Systematic Review.International journal of chronic obstructive pulmonary disease · 2026Pooled it
- Pretransplant Small-airway Dysfunction is Associated with Posttransplant Complications in Adult HSCT Recipients.Thoracic research and practice · 2026Article
- Artificial Intelligence-Enhanced Spirometry in Primary Healthcare: Opportunities for Early Detection of Small Airway Dysfunction.Healthcare (Basel, Switzerland) · 2026Review
- Respiratory oscillometry in patients with chronic obstructive pulmonary disease with airway mucus plugs: insights from the ECLIPSE study.American journal of respiratory and critical care medicine · 2026Article
- An Interpretable Multidimensional Acoustic Physiology Map for COPD Using Digital Lung Sounds.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026Article
- The effect of industry-related air pollution on pulmonary function: A prospective, cross-sectional comparative study of industrial proximity and smoking status.The Journal of international medical research · 2026Article
- Impact of bronchodilator responsiveness on lung age in patients with respiratory diseases and/or symptoms: implications for clinical practice from a cross-sectional study.Journal of thoracic disease · 2026Article
- Time-Frequency Respiratory Impedance Maps Enable Within-Breath Deep Learning for Small Airway Dysfunction Identification.Bioengineering (Basel, Switzerland) · 2026Article
- Reference Values for Respiratory Impedance in Bulgarian Children Aged 2-8 Years Using the Forced Oscillation Technique (FOT).Children (Basel, Switzerland) · 2025Article
- Respiratory abnormalities in sarcoidosis: physiopathology and early diagnosis using oscillometry combined with respiratory modeling.BMC pulmonary medicine · 2025Observational
- Prediction of Abnormal Functional Performance in Chronic Obstructive Pulmonary Disease Using Respiratory Models: A Pilot Study.International journal of chronic obstructive pulmonary disease · 2025Article
- Beyond the Spirometry: New Diagnostic Modalities in Chronic Obstructive Pulmonary Disease.Tuberculosis and respiratory diseases · 2025Article
- Prevalence and Risk Factors of Spirometry-Defined Small Airway Dysfunction in the High-Risk Population for COPD in Yunnan Province, China: A Population Based Cross-Sectional Study.International journal of chronic obstructive pulmonary disease · 2025Article
- Small airway disease as a key factor in COPD: new perspectives and insights.Frontiers in medicine · 2025Review
- Association between pulmonary ventilation function and cognitive function among middle-aged and older adults: an observational study from Southwest China.BMC pulmonary medicine · 2024Observational
- An Italian Delphi Consensus on the Triple inhalation Therapy in Chronic Obstructive Pulmonary Disease.Multidisciplinary respiratory medicine · 2024Article
- Article
- Reference equations using segmented regressions for impulse oscillometry in healthy subjects aged 2.7-90 years.ERJ open research · 2023Article
- Analysis of influencing factors and a predictive model of small airway dysfunction in adults.BMC pulmonary medicine · 2023Article
- Lung function measurements in preclinical research: What has been done and where is it headed?Frontiers in physiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
It is increasingly acknowledged that delays in the diagnosis of chronic inflammatory lung conditions have hampered our understanding of pathogenesis and thus our ability to design efficacious therapies. This is particularly true for COPD, where most patients are diagnosed with moderate-to-severe airflow obstruction and little is known about the inflammatory processes present in early disease. There is great interest in developing screening tests that can identify those most at risk of developing COPD before airflow obstruction has developed for the purpose of research and clinical care. Landmark pathology studies have suggested that damage to the small airways precedes the development of airflow obstruction and emphysema and, thus, presents an opportunity to identify those at risk of COPD. However, despite a number of physiological tests being available to assess small airways function, none have been adopted into routine care in COPD. The reasons that tests of small airways have not been utilized widely include variability in test results and a lack of validated reference ranges from which to compare results for some methodologies. Furthermore, population studies have not consistently demonstrated their ability to diagnose disease. However, the landscape may be changing. As the equipment that delivers tests of small airways become more widely available, reference ranges are emerging and newer methodologies specifically seek to address variability and difficulty in test performance. Moreover, there is evidence that while tests of small airways may not be helpful across the full range of established disease severity, there may be specific groups (particularly those with early disease) where they might be informative. In this review, commonly utilized tests of small airways are critically appraised to highlight why these tests may be important, how they can be used and what knowledge gaps remain for their use in COPD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.