ArticleClinical interventions in aging2017
MRI assessment of whole-brain structural changes in aging.
Article in Clinical interventions in aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
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- Importance of radiation-related cognitive decline in older adults who receive cranial radiation.Expert review of anticancer therapy · 2025Review
- Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances.Signal transduction and targeted therapy · 2025Review
- Joint Aging Patterns in Brain Function and Structure Revealed Using 27,793 Samples.Research (Washington, D.C.) · 2025Article
- Arteriolar neuropathology in cerebral microvascular disease.Neuropathology and applied neurobiology · 2023Review
- Assessment of structural brain changes in patients with type 2 diabetes mellitus using the MRI-based brain atrophy and lesion index.Neural regeneration research · 2022Article
- 3D hemisphere-based convolutional neural network for whole-brain MRI segmentation.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2022Article
- Normal-sized basal ganglia perivascular space related to motor phenotype in Parkinson freezers.Aging · 2021Article
- Article
- Apolipoprotein E ε4 Allele-Based Differences in Brain Volumes Are Largely Uniform Across Late Middle Aged and Older Hispanic/Latino- and Non-Hispanic/Latino Whites Without Dementia.Frontiers in aging neuroscience · 2021Article
- Aging Brains Degrade Driving Safety Performances of the Healthy Elderly.Frontiers in aging neuroscience · 2021Article
- Age-Related Alterations in Brain Perfusion, Venous Oxygenation, and Oxygen Metabolic Rate of Mice: A 17-Month Longitudinal MRI Study.Frontiers in neurology · 2020Article
- Association of Brain Atrophy and Masseter Sarcopenia With 1-Year Mortality in Older Trauma Patients.JAMA surgery · 2019Article
- Imaging the aged brain: pertinence and methods.Quantitative imaging in medicine and surgery · 2019Review
- The Conjoint Analysis of Microstructural and Morphological Changes of Gray Matter During Aging.Frontiers in neurology · 2019Article
- Age-Related Whole-Brain Structural Changes in Relation to Cardiovascular Risks Across the Adult Age Spectrum.Frontiers in aging neuroscience · 2019Article
- Frailty, nutrition-related parameters, and mortality across the adult age spectrum.BMC medicine · 2018Article
- Reliability of the MRI-based Brain Atrophy and Lesion Index in the evaluation of whole-brain structural health.Aging medicine (Milton (N.S.W)) · 2018Article
- Toward MRI-based whole-brain health assessment: The brain atrophy and lesion index (BALI).Aging medicine (Milton (N.S.W)) · 2018Review
- Factors associated with attitudes toward research MRI in older Asian Americans.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
purposeOne of the central features of brain aging is the accumulation of multiple age-related structural changes, which occur heterogeneously in individuals and can have immediate or potential clinical consequences. Each of these deficits can coexist and interact, producing both independent and additive impacts on brain health. Many of the changes can be visualized using MRI. To collectively assess whole-brain structural changes, the MRI-based Brain Atrophy and Lesion Index (BALI) has been developed. In this study, we validate this whole-brain health assessment approach using several clinical MRI examinations. MATERIALS AND
methodsData came from three independent studies: the Alzheimer's Disease Neuroimaging Initiative Phase II (n=950; women =47.9%; age =72.7±7.4 years); the National Alzheimer's Coordinating Center (n=722; women =55.1%; age =72.7±9.9 years); and the Tianjin Medical University General Hospital Research database on older adults (n=170; women =60.0%; age =62.9±9.3 years). The 3.0-Tesla MRI scans were evaluated using the BALI rating scheme on the basis of T1-weighted (T1WI), T2-weighted (T2WI), T2-weighted fluid-attenuated inversion recovery (T2-FLAIR), and T2*-weighted gradient-recalled echo (T2*GRE) images.
resultsAtrophy and lesion changes were commonly seen in each MRI test. The BALI scores based on different sequences were highly correlated (Spearman
conclusionThe T1WI- and T2WI-based BALI evaluations consistently identified the burden of aging and dementia-related decline of structural brain health. Inclusion of additional MRI tests increased lesion differentiation. Further research is to integrate MRI tests for a clinical tool to aid the diagnosis and intervention of brain aging.
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